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ISG20 — STAT1
Text-mined interactions from Literome
Plumlee et al., Virology journal 2005
:
Stat1 and Stat2 combine with the IRF-9 protein to form the transcription factor interferon stimulated gene factor 3 ( ISGF-3 ), which binds to the interferon stimulated response element ( ISRE ), and
induces transcription of IFN-alpha induced genes (
ISG )
Zhang et al., Biochim Biophys Acta 2006
(Carcinoma, Hepatocellular...) :
Hyper activated IRF-1 and
STAT1 contribute to enhanced
interferon stimulated gene ( ISG ) expression by interferon alpha and gamma co-treatment in human hepatoma cells
Byrnes-Blake et al., J Interferon Cytokine Res 2012
(Hepatitis C, Chronic) :
However,
STAT1 phosphorylation, MHC class 1 upregulation, and
ISG induction in leukocytes only occurred with IFNa
Kumthip et al., J Virol 2012
:
We propose a model in which the binding of the C-terminal region of NS5A to
STAT1 leads to decreased levels of P-STAT1, ISRE signaling, and
ISG transcription and, ultimately, to preferential GT1 resistance to IFN treatment