◀ Back to CXCL12
CDKN1C — CXCL12
Text-mined interactions from Literome
Zhao et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2012
(Myelodysplastic Syndromes) :
The
effect of
SDF-1 on
p57kip2 expression in bone marrow mononuclear cell ( BMMNC ) from MDS or normal controls was investigated in vitro, and difference between them was compared ... Moreover,
SDF-1 increased
p57kip2 expression in normal BMMNC in dose dependent manner, but BMMNC from MDS patients showed no response to SDF-1 ... Furthermore,
SDF-1 induced
p57kip2 expression in BMMNC, and the decreasing response of BMMNC to SDF-1 may contribute to the low expression of p57kip2 in MDS patients
Zhao et al., Hematology 2012
(Leukemia, Myeloid, Acute...) :
SDF-1/CXCR4 signal is
involved in decreased expression of
p57kip2 in de novo MDS patients ... We also searched the
role of
stromal cell derived factor-1 (SDF-1)/CXCR4 signal in
p57kip2 expression in vitro ... We also searched the
role of stromal cell derived factor-1
(SDF-1)/CXCR4 signal in
p57kip2 expression in vitro ... p57kip2 expression in bone marrow mononuclear cells of normal controls increased significantly when co-cultured with SDF-1 in vitro, which could be blocked by AMD3100, whereas
SDF-1 only
induced a mild increase in
p57kip2 in MDS ... Reduced response to
SDF-1 contributed to low expression of
p57kip2 in MDS cases