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EGF — NEUROD6
Text-mined interactions from Literome
Kusumoto et al., In Vitro Cell Dev Biol Anim 2009
:
Maximum mitogenic stimulation with 50 ng/mL
EGF blocked the BMP-4 effect on
neuronal differentiation , but did not block TGF-beta induced expression of markers of the astrocytic lineage
den Hertog et al., Cell Growth Differ 1991
:
Interestingly,
neuronal differentiation is induced in these cells in
response to
EGF under culture conditions resembling those during early preimplantation embryogenesis
Teng et al., J Biol Chem 1995
:
Nerve growth factor (NGF) and
epidermal growth factor (EGF) elicit contrasting actions on PC12 pheochromocytoma cells ; NGF
causes neuronal differentiation , and EGF induces proliferation
Traverse et al., Curr Biol 1994
:
EGF triggers
neuronal differentiation of PC12 cells that overexpress the EGF receptor
Yamada et al., Neurochem Res 1996
:
EGF induced sustained tyrosine phosphorylation and decreased rate of down-regulation of EGF receptor in PC12h-R cells which show
neuronal differentiation in
response to
EGF ... We examined the mechanism by which
EGF induced the
neuronal differentiation in PC12h-R cells ... The
EGF induced
neuronal differentiation of PC12h-R cells was not blocked by K252a, whereas that induced by NGF was ... EGF induced sustained tyrosine phosphorylation of the EGF receptor in PC12h-R cells, but not in the parent PC12h cells, which do not show
neuronal differentiation in
response to
EGF ... These findings suggested that the
EGF induced
neuronal differentiation of PC12h-R cells is due to the sustained activation of the EGF receptor, resulting from the decreased down-regulation of the EGF receptor and that the duration of the receptor tyrosine kinase activity determines the cellular responses of PC12 cells