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NODAL — SMAD3
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
NODAL
—
SMAD3
(interaction, mapped from reactome intact)
-
STRING interaction:
SMAD3
—
NODAL
(interaction, mapped from reactome intact)
Text-mined interactions from Literome
Dunn et al., Development 2004
:
TGFbeta/activin/Nodal receptors
activate both Smad2 and
Smad3 intracellular effector proteins
Esguerra et al., Development 2007
:
Ttrap is an essential modulator of
Smad3 dependent
Nodal signaling during zebrafish gastrulation and left-right axis determination ... Stimulation of Alk4/EGF-CFC receptor complexes by
Nodal activates
Smad2/3 , leading to left sided expression of target genes that promote asymmetric placement of certain internal organs ... Thus, although the
role of
Smad proteins in mediating
Nodal signaling is well documented, the functional characterization of Ttrap provides insight into a novel Smad partner that plays an essential role in the fine tuning of this signal transduction cascade
D'Andrea et al., J Cell Biol 2008
:
In cripto ( F78A/F78A ) mouse embryos, Nodal fails to expand its own expression domain and that of cripto, indicating that F78 is essential in vivo to stimulate
Smad dependent
Nodal autoinduction
He et al., Stem Cells 2009
:
Nodal activates
Smad2/3 phosphorylation, Oct-4 transcription, cyclin D1, and cyclin E expression, whereas SB431542 completely abolishes their increase
Vo et al., Prostate 2011
(Prostatic Neoplasms) :
RT-PCR, qPCR, and Western blot analyses were performed to analyze expression of Nodal and
Nodal receptors and its
effects on phosphorylation of
Smad2/3 in prostate cells
Xi et al., Cell 2011
:
Nodal receptors
induce the formation of companion
Smad4-Smad2/3 and TRIM33-Smad2/3 complexes
De Silva et al., Frontiers in endocrinology 2012
:
To determine which receptor and
Smad mediate the growth promoting effect of
Nodal , we transfected siRNAs targeting ALK4, ALK7, Smad2, or Smad3 into Nodal overexpressing cells and observed that cell growth was significantly inhibited by ALK4, ALK7, and Smad3 siRNAs ... Taken together, these findings suggest that
Nodal may have tumor promoting effects on glioblastoma cells and these effects are
mediated by ALK4, ALK7, and
Smad3