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RHOA — WNT3A

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of DVL2-DVL3-PRKCA-RHOA → WNT3A (increases)
  Evidence: PKCa, PCKb, and PKCmu were associated with both Dvl-2 (Figure 8A) and Dvl-3 (Figure 8B), suggesting that several PKCs are likely included in the Dvl/RhoA complex.
• OpenBEL Selventa BEL large corpus: Complex of DVL2-DVL3-PRKCB-RHOA → WNT3A (increases)
  Evidence: PKCa, PCKb, and PKCmu were associated with both Dvl-2 (Figure 8A) and Dvl-3 (Figure 8B), suggesting that several PKCs are likely included in the Dvl/RhoA complex.

Text-mined interactions from Literome

Endo et al., J Biol Chem 2005 : The small GTPase RhoA also was activated by Wnt-3a
Rossol-Allison et al., Cell Signal 2009 : While the importance of activated Rho to non-canonical Wnt signaling is well appreciated, the potential contribution of Wnt3A stimulated RhoA to canonical beta-catenin dependent transcription has not been examined and is the focus of this study
Steele et al., Proc Natl Acad Sci U S A 2009 : Wnt3a also altered platelet shape change and inhibited the activation of the small GTPase RhoA
Tsuji et al., Mol Biol Cell 2010 (Neuroblastoma) : Here we identified p114-RhoGEF and Lfc ( also called GEF-H1 ) as the Rho-GEFs responsible for Wnt-3a induced RhoA activation in N1E-115 mouse neuroblastoma cells ... p114-RhoGEF and Lfc shRNAs also inhibited Dvl- and Wnt-3a induced RhoA activation, and p114-RhoGEF and Lfc proteins were capable of binding to Dvl and Daam1