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APAF1 — HSP90AA1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: APAF1 — HSP90AA1 (direct interaction, unspecified method) Burch et al., J Mol Biol 2004
• IRef Biogrid Interaction: APAF1 — HSP90AA1 (physical association, affinity chromatography technology) Saleh et al., Nat Cell Biol 2000*

Text-mined interactions from Literome

Zhang et al., Virology journal 2011 (Influenza, Human) : Significantly, the NS1 expression in the A549 cells dramatically weakened the interaction between Apaf-1 and Hsp90 but enhanced its interaction with cytochrome c ( Cyt c ), suggesting that the competitive binding of NS1 to Hsp90 might promote the Apaf-1 to associate with Cyt c and thus facilitate the activation of caspase 9 and caspase 3
Ferraro et al., J Cell Sci 2011 : By analyzing Apaf1 depleted cells, we have found that Apaf1 loss induces centrosome defects that impair centrosomal microtubule nucleation and cytoskeleton organization