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TP53 — TYR

Text-mined interactions from Literome

Nylander et al., J Pathol 2000 : Transcriptional activation of tyrosinase and TRP-1 by p53 links UV irradiation to the protective tanning response
Khlgatian et al., J Invest Dermatol 2002 (Melanoma) : Tyrosinase gene expression is regulated by p53 ... To determine whether p53 activation is required for this increased tyrosinase expression, we employed two experimental systems : ( i ) a human melanoma line ( WM35 ) known to express wild-type p53 versus WM35 cells engineered to express a transcriptionally inactive dominant negative p53 ( WM35-p53DN ) or the empty vector alone ( WM35-pCMV7 ) and ( ii ) mice with wild-type p53 versus p53 knockout mice ... Together, these data demonstrate that p53 activation increases tyrosinase mRNA level and subsequently pigmentation
Thangasamy et al., Cell Oncol 2008 (Melanoma, Experimental) : Tyrosinase overexpression promotes ATM dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine ... Therefore, this study demonstrates that tyrosinase overexpression promotes an ATM dependent p53 phosphorylation by Qct treatment and sensitizes melanoma cells to dacarbazine
Kichina et al., Pigment Cell Res 1996 (Melanoma) : In order to determine whether the p53 repression of tyrosinase mRNA involved modulation of tyrosinase promoter activity, transient transfection approaches involving p53 expression plasmid and construct containing chloramphenicol acetyl transferase (CAT) reporter gene linked to 270 bp tissue-specific tyrosinase promoter have been used