◀ Back to TP53
SMARCA4 — TP53
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Direct p53 effectors:
BRG1 (SMARCA4)
→
p53 (tetramer) complex (TP53)
(transcription, activates)
Le Cam et al., Cell 2006, Harms et al., Cancer Res 2007, Shi et al., Mol Cell 2007, Das et al., Cell 2007, Xu et al., J Biol Chem 2007, Gamper et al., Mol Cell Biol 2008, el-Deiry et al., Cancer Res 1995
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Direct p53 effectors:
BRG1 (SMARCA4)
→
p53 (tetramer) complex (TP53)
(transcription, activates)
Harms et al., Cancer Res 2007, Shi et al., Mol Cell 2007, Das et al., Cell 2007, Xu et al., J Biol Chem 2007, Gamper et al., Mol Cell Biol 2008, Tang et al., Cell 2008, el-Deiry et al., Cancer Res 1995
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Direct p53 effectors:
BRG1 (SMARCA4)
→
p53 (tetramer) complex (TP53)
(transcription, activates)
Harms et al., Cancer Res 2007, Shi et al., Mol Cell 2007, Das et al., Cell 2007, Xu et al., J Biol Chem 2007, Gamper et al., Mol Cell Biol 2008, Jansson et al., Nat Cell Biol 2008, el-Deiry et al., Cancer Res 1995
Evidence: mutant phenotype, reporter gene, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
SMARCA4
—
TP53
(physical association, affinity chromatography technology)
Napolitano et al., J Cell Sci 2007*
-
IRef Biogrid Interaction:
SMARCA4
—
TP53
(physical association, affinity chromatography technology)
Guan et al., Cancer Res 2011*
-
IRef Biogrid Interaction:
SMARCA4
—
TP53
(physical association, affinity chromatography technology)
Oh et al., J Biol Chem 2008*
-
IRef Biogrid Interaction:
SMARCA4
—
TP53
(colocalization, biochemical)
Lee et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
SMARCA4
—
TP53
(direct interaction, pull down)
Lee et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
SMARCA4
—
TP53
(physical association, affinity chromatography technology)
Lee et al., J Biol Chem 2002*
-
IRef Hprd Interaction:
Complex of 17 proteins
(in vivo)
Oh et al., J Biol Chem 2008*
-
IRef Hprd Interaction:
TP53
—
SMARCA4
(in vitro)
Lee et al., J Biol Chem 2002*
-
IRef Hprd Interaction:
TP53
—
SMARCA4
(in vivo)
Lee et al., J Biol Chem 2002*
-
IRef Intact Interaction:
Complex of SMARCC1-SMARCA4-TP53
(association, anti bait coimmunoprecipitation)
Oh et al., J Biol Chem 2008*
-
IRef Ophid Interaction:
SMARCA4
—
TP53
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
SMARCA4
—
TP53
(aggregation, confirmational text mining)
Lee et al., J Biol Chem 2002*
Text-mined interactions from Literome
Long et al., Apoptosis 2002
:
The level of phosphorylated
p53 was increased as a
result of
BAF or STAU-treatment
Wang et al., J Biochem 2007
:
In this study, we show that
BAF53 is
involved in the repression of p53 dependent p21-gene transcription by interacting with
p53 both in vivo and in vitro