◀ Back to TP53
SIRT1 — TP53
Pathways - manually collected, often from reviews:
-
BioCarta regulation of transcriptional activity by pml:
SIRT1
→
p53 (TP53)
(modification, activates)
-
NCI Pathway Database Signaling events mediated by HDAC Class III:
p53 (TP53)
→
SIRT1 (SIRT1)
(modification, collaborate)
Luo et al., Cell 2001*, Vaziri et al., Cell 2001*, Langley et al., EMBO J 2002*
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class III:
p53 (TP53)
→
p53/SIRT1 complex (TP53-SIRT1)
(modification, collaborate)
Luo et al., Cell 2001*, Vaziri et al., Cell 2001*, Langley et al., EMBO J 2002*
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class III:
SIRT1 (SIRT1)
→
p53/SIRT1 complex (TP53-SIRT1)
(modification, collaborate)
Luo et al., Cell 2001*, Vaziri et al., Cell 2001*, Langley et al., EMBO J 2002*
Evidence: assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
TP53
—
SIRT1
Cohen et al., Science 2004*
-
IRef Bind_translation Interaction:
TP53
—
SIRT1
(experimental interaction detection)
Cohen et al., Science 2004*
-
IRef Biogrid Interaction:
SIRT1
—
TP53
(physical association, affinity chromatography technology)
Jain et al., PLoS Biol 2012*
-
IRef Biogrid Interaction:
SIRT1
—
TP53
(direct interaction, enzymatic study)
Langley et al., EMBO J 2002*
-
IRef Biogrid Interaction:
SIRT1
—
TP53
(direct interaction, pull down)
Langley et al., EMBO J 2002*
-
IRef Biogrid Interaction:
SIRT1
—
TP53
(physical association, affinity chromatography technology)
Langley et al., EMBO J 2002*
-
IRef Biogrid Interaction:
SIRT1
—
TP53
(physical association, affinity chromatography technology)
Kim et al., Nature 2008
-
IRef Biogrid Interaction:
SIRT1
—
TP53
(direct interaction, enzymatic study)
Kim et al., Nature 2008
-
IRef Biogrid Interaction:
SIRT1
—
TP53
(physical association, affinity chromatography technology)
Zhao et al., Nature 2008*
-
IRef Biogrid Interaction:
SIRT1
—
TP53
(physical association, affinity chromatography technology)
Liu et al., Proc Natl Acad Sci U S A 2011*
-
IRef Biogrid Interaction:
SIRT1
—
TP53
(physical association, affinity chromatography technology)
Inoue et al., J Biol Chem 2011*
-
MIPS CORUM hSIR2-p53 complex:
hSIR2-p53 complex complex (SIRT1-TP53)
Vaziri et al., Cell 2001*
-
IRef Corum Interaction:
TP53
—
SIRT1
(association, anti bait coimmunoprecipitation)
Vaziri et al., Cell 2001*
-
IRef Dip Interaction:
TP53
—
SIRT1
(direct interaction, deacetylase assay)
Kim et al., Nature 2008
-
IRef Dip Interaction:
TP53
—
SIRT1
(direct interaction, anti bait coimmunoprecipitation)
Liu et al., Proc Natl Acad Sci U S A 2011*
-
IRef Dip Interaction:
TP53
—
SIRT1
(direct interaction, acetylase assay)
Zhao et al., Nature 2008*
-
IRef Dip Interaction:
TP53
—
SIRT1
(direct interaction, anti tag coimmunoprecipitation)
Zhao et al., Nature 2008*
-
IRef Dip Interaction:
TP53
—
SIRT1
(direct interaction, anti tag coimmunoprecipitation)
Kim et al., Nature 2008
-
IRef Hprd Interaction:
TP53
—
SIRT1
(in vitro)
Vaziri et al., Cell 2001*
-
IRef Hprd Interaction:
TP53
—
SIRT1
(in vivo)
Vaziri et al., Cell 2001*
-
IRef Intact Interaction:
Complex of SIRT1-TP53-RPS19BP1
(association, anti bait coimmunoprecipitation)
Kim et al., Mol Cell 2007*
-
IRef Intact Interaction:
Complex of PML-SIRT1-TP53
(colocalization, imaging technique)
Langley et al., EMBO J 2002*
-
IRef Intact Interaction:
TP53
—
SIRT1
(deacetylation reaction, deacetylase assay)
Cohen et al., Science 2004*
-
IRef Intact Interaction:
TP53
—
SIRT1
(physical association, anti bait coimmunoprecipitation)
Vaziri et al., Cell 2001*
-
IRef Intact Interaction:
TP53
—
SIRT1
(physical association, anti bait coimmunoprecipitation)
Langley et al., EMBO J 2002*
-
IRef Intact Interaction:
TP53
—
SIRT1
(direct interaction, pull down)
Langley et al., EMBO J 2002*
-
IRef Intact Interaction:
TP53
—
SIRT1
(deacetylation reaction, deacetylase assay)
Langley et al., EMBO J 2002*
-
IRef Intact Interaction:
TP53
—
SIRT1
(direct interaction, deacetylase assay)
Kim et al., Mol Cell 2007*
-
IRef Intact Interaction:
TP53
—
SIRT1
(deacetylation reaction, deacetylase assay)
Kim et al., Nature 2008
-
IRef Ophid Interaction:
TP53
—
SIRT1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Vaziri et al., Cell 2001
:
Expression of wild-type
hSir2 in human cells
reduces the transcriptional activity of
p53
Ford et al., Cancer Res 2005
:
Combined gene knockout with RNAi cosilencing experiments indicate that
SIRT1 and Bcl-2 may suppress separable apoptotic pathways in the same cell lineage and that the SIRT1 regulated pathway is
independent of
p53 , Bax, and caspase-2
Kamel et al., Aging Cell 2006
:
Upon re-examination of the
role of
SirT1 in modulating
p53 activity, we found that while SirT1 interacts with p53, the SirT1 protein had little effect on p53 dependent transcription of transfected or endogenous genes and did not affect the sensitivity of thymocytes and splenocytes to radiation induced apoptosis
Xi et al., Acta Pharmacol Sin 2008
:
Importantly, the inhibition of
SIRT1 contributed to the activation of
p53 and the inactivation of the PI3-K/Akt signaling pathway increased the expression of the p53 protein and downregulated the SIRT1 protein expression
Han et al., Cell stem cell 2008
:
SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling
p53 subcellular localization ... Although SIRT1, a p53 deacetylase, inhibits
p53 mediated transactivation, how
SIRT1 regulates these p53 multifunctions is unclear
Yamakuchi et al., Proc Natl Acad Sci U S A 2008
:
MiR-34 inhibition of
SIRT1 leads to an increase in acetylated
p53 and expression of p21 and PUMA, transcriptional targets of p53 that regulate the cell cycle and apoptosis, respectively
Pediconi et al., Mol Cell Biol 2009
:
The NAD ( + ) -dependent histone deacetylase
hSirT1 regulates cell survival and stress responses by inhibiting
p53- , NF-kappaB-, and E2F1 dependent transcription
Jung-Hynes et al., Cell cycle (Georgetown, Tex.) 2009
(Prostatic Neoplasms) :
Since p53 is a target for deacetylation by Sirt1, we wanted to determine the
involvement of
p53 in
Sirt1 inhibition mediated responses in PCa
van Leeuwen et al., Adv Cancer Res 2009
(Neoplasms) :
Preliminary observations also suggest that
sirtuin mediated modulation of
p53 can also take place indirectly through changes in cellular processes ( e.g., nucleolar function and p300 activity ) known to affect p53
Gagarina et al., Arthritis Rheum 2010
(Osteoarthritis) :
Expression of
SirT1 in chondrocytes led to activation of IGFR and the downstream kinases phosphatidylinositol 3-kinase, phosphoinosite dependent protein kinase 1, mTOR, and Akt, which in turn phosphorylated MDM2,
inhibited p53 , and blocked apoptosis
Lynch et al., PloS one 2010
:
Thus,
SIRT1 mediated inhibition of
p53 has been identified as a key node in the common biology of cancer, metabolism, development and ageing ... We also identify an auto-regulatory loop whereby
SIRT1-dExon8 can
regulate p53 , while in reciprocal p53 can influence SIRT1 splice variation
Seo et al., Neurobiol Aging 2012
:
Resveratrol mediated SIRT1 activation decreased the acetylation of
p53 and p65
induced by prion protein and
SIRT1 inhibitor
Liu et al., Proc Natl Acad Sci U S A 2011
:
Methyltransferase Set7/9
regulates p53 activity by interacting with
Sirtuin 1 (SIRT1)
Rodella et al., Age (Dordrecht, Netherlands) 2013
(Atherosclerosis...) :
We demonstrate that
SIRT1 and eNOS decresed in APOE mice between 6 and 15 weeks and that aging
induced an elevated expression of
p53 and ET-1 in APOE animals
Dixit et al., Cell death & disease 2012
(Brain Neoplasms...) :
This ability of CK2-Is to sensitize glioma to TNFa induced death via multiple mechanisms involving abrogation of NF-?B activation, reactivation of wild-type
p53 function and
SIRT1 inhibition warrants investigation
Li et al., Cancer Cell 2012
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Activation of
p53 by
SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib ...
Activation of
p53 via
SIRT1 inhibition represents a potential approach to target CML LSC
Xie et al., Cancer Sci 2012
(Carcinoma, Hepatocellular...) :
The current findings indicate that
SirT1 confers a higher radioresistance in hypoxic cells than in normoxic cells due to the decreased levels of c-Myc protein and its acetylation, and that a c-Myc dependent radiation induced phosphorylated
p53 may be
involved
Busch et al., J Biol Chem 2012
(Tendinopathy) :
Overall, these results suggest for the first time that
Sirt-1 can
regulate p53 and NF-?B signaling via deacetylation, demonstrating a novel role for resveratrol in the treatment of tendinitis/tendinopathy
Castro et al., J Hepatol 2013
(Fatty Liver...) :
Finally,
p53 overexpression
activated miR-34a/SIRT1/p53 , which in turn was inhibited by UDCA, via decreased p53 transcriptional activity
van Leeuwen et al., Mol Cancer Ther 2013
:
These results help understand why inhibition of both SirT1 and SirT2 is needed to achieve effective
activation of
p53 by small-molecule
sirtuin inhibitors
Adlakha et al., Cell death & disease 2013
:
miR-128 inhibition of
SIRT1 led to an increase in acetylated
p53 and its transcriptional targets