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SERPINE1 — TP53
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
TP53
—
SERPINE1
(interaction, mapped from intact)
-
STRING interaction:
TP53
—
SERPINE1
(interaction, mapped from intact)
-
STRING interaction:
SERPINE1
—
TP53
(interaction, mapped from grid dip)
-
STRING interaction:
SERPINE1
—
TP53
(interaction, mapped from grid dip)
Text-mined interactions from Literome
Vidal et al., Thromb Haemost 2005
:
We previously demonstrated that MNNG induced the transcriptional activity of the plasminogen activator inhibitor-1 (
PAI-1 ) gene in a
p53 dependent manner ... Finally, we showed that cells derived from PAI-1-deficient mice were more resistant to MNNG induced cell death than normal cells, suggesting that
p53 dependent
PAI-1 expression partially mediated this effect
Bove et al., J Biol Chem 2008
(Inflammation) :
Finally, NO-mediated inhibition of cell migration was associated with HIF-1alpha dependent induction of
PAI-1 and
activation of
p53 , both negative regulators of epithelial cell migration
Shetty et al., J Biol Chem 2008
(Carcinoma, Non-Small-Cell Lung...) :
Transfection of
p53 in p53 ( -/- ) cells
enhanced PAI-1 expression and stabilized PAI-1 mRNA
Huang et al., Am J Respir Cell Mol Biol 2012
(Body Weight...) :
Furthermore, we show that TM5275 induced apoptosis in both myofibroblasts ( TGF-ß1 treated ) and naive ( TGF-ß1 untreated ) human lung fibroblasts, and this apoptosis was associated with the activation of caspase-3/7, the
induction of
p53 , and the inhibition of a-smooth muscle actin, fibronectin, and
PAI-1 expression
Samarakoon et al., Cell Signal 2013
(Fibrosis) :
Recent findings suggest a novel
role for
p53 in TGF-ß1 induced
PAI-1 transcription that involves ROS generation and p53/SMAD interactions