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S100A6 — TP53

Pathways - manually collected, often from reviews:

• WikiPathways Gastric Cancer Network 2: TP53 → S100A6 (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: TP53 — S100A6 (direct interaction, molecular sieving) van Dieck et al., FEBS Lett 2010

Text-mined interactions from Literome

Króliczak et al., Acta biochimica Polonica 2008 (Neoplasms) : Separate overexpression of either Sp1 or of NFkappaB only partially counteracted the p53 inhibitory effect on the S100A6 promoter, while simultaneous overexpression of both these transactivators resulted in a complete abolishment of the p53 inhibitory effect on this promoter
Tsoporis et al., J Biol Chem 2008 (Inflammation) : These results demonstrate that S100A6 is induced by tumor necrosis factor-alpha via an NF-kappaB dependent mechanism, serving a role in homeostasis to limit tumor necrosis factor-alpha induced apoptosis by regulating p53 phosphorylation
Słomnicki et al., Int J Biochem Cell Biol 2009 : As revealed by electrophoretic mobility shift assay ( EMSA ) S100A6 does not affect p53 binding to DNA
Zimmermann et al., Proteomics 2009 : Proteomic profiling in distinct cellular compartments of tumor cells reveals p53 dependent upregulation of S100A6 upon induction of telomere dysfunction