◀ Back to TP53
KLF4 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wang et al., J Biochem 2008
:
We also show that overexpression of
KLF4 in VSMCs
increased the expression of
p53 , SM22alpha and alpha-SMA, but decreased the expression of SMemb and VSMC proliferation and migration
Zhou et al., Cancer Res 2009
:
KLF4 is
activated by
p53 following cytostatic, mild DNA damage, whereas it is strongly repressed via enhanced turnover of mRNA on severe DNA damage that irreversibly drives cells to apoptosis
Brosh et al., Cell Death Differ 2013
:
We found that
p53 restricts MET during the early phases of reprogramming and that this effect is primarily
mediated by the ability of p53 to inhibit
Klf4 dependent activation of epithelial genes
Brandt et al., PloS one 2012
:
Here, we present evidence that
KLF4 increases the DNA binding affinity of
p53 through the formation of a loosely arranged ternary complex on DNA
Ren et al., Int J Oncol 2013
(Prostatic Neoplasms) :
Moreover,
WT-p53 also
suppressed colony formation, tumor sphere formation and expression of CSC markers and stemness factors including CD44, Oct4, c-Myc and
Klf4 in PC-3 cells