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HMGB2 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yoshida et al., Cancer Res 2003
:
Interaction between mtTFA and
p53 required the high mobility group-box1 or
high mobility group-box2 of mtTFA and amino acids 363-376 of p53
Lee et al., Cancer Lett 2010
:
HMGB2 stabilizes
p53 by interfering with E6/E6AP mediated p53 degradation in human papillomavirus positive HeLa cells ... Overexpression of
HMGB2 led to accumulation of the
p53 protein, whereas HMGB2 knockdown with siRNA resulted in a substantial decrease in the p53 protein level ... The
HMGB2 dependent increase of
p53 stability was specific for HPV positive HeLa cells as HCT116 and MCF7 cell lines did not demonstrate this response ... Our findings collectively suggest that
HMGB2 could
stabilize p53 by interfering with E6/E6AP mediated p53 degradation in HPV positive HeLa cells
Shin et al., Cancer Biol Ther 2013
(Colorectal Neoplasms) :
p53 mediated downregulation of
HMGB2 was confirmed by direct activation of p53 using Nutlin-3 or by inducing p53 expression using Tet-On system