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APAF1 — TP53
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Moroni et al., Nat Cell Biol 2001
:
Apaf-1 is a transcriptional
target for E2F and
p53
Robles et al., Cancer Res 2001
(Colorectal Neoplasms) :
Consistently,
p53 directly
induced APAF-1 gene expression
Fortin et al., J Cell Biol 2001
(Brain Ischemia) :
APAF1 is a key transcriptional
target for
p53 in the regulation of neuronal cell death ... In the present study, we demonstrate that
p53 directly
upregulates Apaf1 transcription as a critical step in the induction of neuronal cell death ... We addressed whether
p53 directly
regulates Apaf1 transcription via the two p53 consensus binding sites in the Apaf1 promoter ... In transient transfections in a neuronal cell line with p53 and Apaf1 promoter-luciferase constructs,
p53 directly
activated the
Apaf1 promoter via both p53 sites ... Together, these results demonstrate that
Apaf1 is a key transcriptional
target for
p53 that plays a pivotal role in the regulation of apoptosis after neuronal injury
Shinoura et al., Br J Cancer 2002
(Brain Neoplasms...) :
To determine which gene is
activated by wild type
p53 induction and, in turn, activates
Apaf-1 and caspase-9, we transduced the Bax, p21/WAF1 or Fas gene via adenovirus vector to U251 cells to achieve a similar expression level as that induced by the Adv for p53 in U251 cells
Rozenfeld-Granot et al., Oncogene 2002
:
A positive feedback mechanism in the transcriptional
activation of
Apaf-1 by
p53 and the coactivator Zac-1
Qin et al., Oncogene 2002
(Psoriasis) :
Using normal human skin organ cultures and living epidermal equivalents, we demonstrate that in the proliferative basal layer, removal of KCs via apoptosis had a rapid onset ( beginning within 2 h ) following UV-light exposure generating progressively greater numbers of KCs with thymine dimers as the dose of UV-light was increased ; involved induction of
Apaf-1 , activation of caspase-3, and was
dependent on
p53 activation as addition of a p53 chemical inhibitor blocked the apoptotic response
Li et al., Proc Natl Acad Sci U S A 2002
:
These results indicate that p53 status is an important modulator of NO ( * ) -induced mutagenesis and apoptosis, and suggest that levels of the
Apaf-1 and XIAP proteins, but not mitochondrial depolarization and cytochrome c release, are
regulated by
p53 in these human lymphoblastoid cells
Ho et al., Oncol Rep 2003
:
Tissue-specific
regulation of
Apaf-1 expression by
p53 ... Similarly, we detected a lower Apaf-1 mRNA level in the heart and spleen of p53-/- mice compared with the p53+/+ controls, supporting a transcriptional
upregulation of
Apaf-1 by
p53 ... Taken together, these results demonstrate that
p53 regulation of
Apaf-1 expression is tissue-specific
Khan et al., Mol Cell Neurosci 2005
:
We found that gp120 stimulates
p53 activity and
induces expression of the p53 pro-apoptotic target
Apaf-1 in cultured neurons
Vaughn et al., Cell Death Differ 2007
:
NGF deprivation relieves XIAP by selectively degrading it, whereas DNA damage overcomes XIAP via a
p53 mediated induction of
Apaf-1