Gene interactions and pathways from curated databases and text-mining

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SGK1 — TRPV5

Text-mined interactions from Literome

Embark et al., Cell Physiol Biochem 2004 : The present study aims to explore whether TRPV5 is regulated by the serum and glucocorticoid inducible kinase SGK1 , a kinase transcriptionally upregulated by 1,25 ( OH ) 2D3 ... The effect of ( S422D ) SGK1 on TRPV5 and NHERF2 expressing oocytes is mimicked by SGK1 and SGK3, but not by SGK2, constitutively active ( T308D, S473D ) PKB or inactive ( K127N ) SGK1 ... The observations suggest that SGK1 , SGK3 and NHERF2 regulate TRPV5 and are thus likely to participate in the regulation of calcium homeostasis
Palmada et al., Cell Physiol Biochem 2005 : Requirement of PDZ domains for the stimulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase SGK1 ... As shown recently, TRPV5 is activated by the serum and glucocorticoid inducible kinase SGK1 , a kinase transcriptionally upregulated by 1,25 ( OH ) 2D3