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NTN1 — RAC1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Netrin-mediated signaling events:
RAC1/GDP complex (RAC1)
→
netrin 1/UNC5A complex (NTN1-UNC5A)
(modification, collaborate)
Picard et al., Cell Signal 2009*
Evidence: mutant phenotype
-
NCI Pathway Database Netrin-mediated signaling events:
RAC1/GDP complex (RAC1)
→
netrin 1/DCC/FAK/Fyn/p130 CAS complex (NTN1-DCC-PTK2-FYN-BCAR1)
(modification, collaborate)
Liu et al., J Neurosci 2007
Evidence: mutant phenotype
-
NCI Pathway Database Netrin-mediated signaling events:
netrin 1/DCC/FAK/Fyn/p130 CAS complex (NTN1-DCC-PTK2-FYN-BCAR1)
→
RAC1/GTP complex (RAC1)
(modification, activates)
Liu et al., J Neurosci 2007
Evidence: mutant phenotype
-
NCI Pathway Database Netrin-mediated signaling events:
RAC1/GDP complex (RAC1)
→
netrin 1/DCC/DOCK1/ELMO1 complex (NTN1-DCC-DOCK1-ELMO1)
(modification, collaborate)
Grimsley et al., J Biol Chem 2004, Li et al., Nat Neurosci 2008
Evidence: mutant phenotype, assay
-
Reactome Reaction:
NTN1
→
RAC1
(indirect_complex)
Li et al., Nat Neurosci 2008, Briançon-Marjollet et al., Mol Cell Biol 2008
-
Reactome Reaction:
NTN1
→
RAC1
(reaction)
Li et al., Nat Neurosci 2008, Briançon-Marjollet et al., Mol Cell Biol 2008
Text-mined interactions from Literome
Briançon-Marjollet et al., Mol Cell Biol 2008
:
Trio mediates
netrin-1 induced
Rac1 activation in axon outgrowth and guidance ... We found that Trio interacts with the netrin-1 receptor DCC in mouse embryonic brains and that
netrin-1 induced
Rac1 activation in brain is impaired in the absence of Trio
Quinn et al., Curr Biol 2008
:
These results suggest that
CED-10/Rac1 is asymmetrically activated in
response to the
UNC-6/netrin signal and thereby causes asymmetric recruitment of MIG-10/lamellipodin
van Gils et al., Nat Immunol 2012
(Atherosclerosis...) :
Acting via its receptor, UNC5b,
netrin-1 inhibited the migration of macrophages directed by the chemokines CCL2 and CCL19, activation of the actin remodeling GTPase
Rac1 and actin polymerization ... Acting via its receptor, UNC5b,
netrin-1 inhibited the migration of macrophages directed by the chemokines CCL2 and CCL19, activation of the actin remodeling GTPase
Rac1 and actin polymerization
DeGeer et al., Mol Cell Biol 2013
:
The Rho guanine nucleotide exchange factor ( GEF ) Trio is essential for
Rac1 activation downstream of
netrin-1/DCC , but the molecular mechanisms governing Trio activity remain elusive ... Though the phospho-null mutant Trio ( Y2622F ) retained GEF activity toward Rac1, its expression impaired
netrin-1 induced
Rac1 activation and DCC mediated neurite outgrowth in N1E-115 neuroblastoma cells