Gene interactions and pathways from curated databases and text-mining

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NTN1 — RAC1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Briançon-Marjollet et al., Mol Cell Biol 2008 : Trio mediates netrin-1 induced Rac1 activation in axon outgrowth and guidance ... We found that Trio interacts with the netrin-1 receptor DCC in mouse embryonic brains and that netrin-1 induced Rac1 activation in brain is impaired in the absence of Trio
Quinn et al., Curr Biol 2008 : These results suggest that CED-10/Rac1 is asymmetrically activated in response to the UNC-6/netrin signal and thereby causes asymmetric recruitment of MIG-10/lamellipodin
van Gils et al., Nat Immunol 2012 (Atherosclerosis...) : Acting via its receptor, UNC5b, netrin-1 inhibited the migration of macrophages directed by the chemokines CCL2 and CCL19, activation of the actin remodeling GTPase Rac1 and actin polymerization ... Acting via its receptor, UNC5b, netrin-1 inhibited the migration of macrophages directed by the chemokines CCL2 and CCL19, activation of the actin remodeling GTPase Rac1 and actin polymerization
DeGeer et al., Mol Cell Biol 2013 : The Rho guanine nucleotide exchange factor ( GEF ) Trio is essential for Rac1 activation downstream of netrin-1/DCC , but the molecular mechanisms governing Trio activity remain elusive ... Though the phospho-null mutant Trio ( Y2622F ) retained GEF activity toward Rac1, its expression impaired netrin-1 induced Rac1 activation and DCC mediated neurite outgrowth in N1E-115 neuroblastoma cells