◀ Back to RAC1

HGF — RAC1

Text-mined interactions from Literome

Royal et al., Mol Biol Cell 2000 : Notably, HGF dependent activation of Rac but not Cdc42 is dependent on phosphatidylinositol 3-kinase ... HGF induces activation of the Cdc42/Rac regulated p21 activated kinase (PAK) and c-Jun N-terminal kinase, and translocation of Rac , PAK, and Rho dependent Rho-kinase to membrane ruffles
Miao et al., J Cell Biol 2003 : Ephrin-A1 suppressed HGF induced activation of Rac1 and p21 activated kinase, whereas RhoA activation was retained, leading to the preservation of stress fibers
De Wever et al., FASEB J 2004 (Colonic Neoplasms...) : RhoA inactivation is determined by the epidermal growth factor (EGF)-like repeats of TNC through EGF-receptor signaling that confers a permissive and priming signal for the proinvasive activity of SF/HGF that activates Rac via c-Met
Ishibe et al., Mol Cell 2004 : These data demonstrate that the paxillin-MAPK complex serves as a central regulator of HGF stimulated FAK and Rac activation in the vicinity of focal adhesions, thus promoting the rapid focal adhesion turnover and lamellipodia extension that are required for migratory and tubulogenic responses
Farooqui et al., Exp Cell Res 2006 : Finally, inhibition of GSK-3 also strongly reduces activation of Rac1 and cell scatter in response to hepatocyte growth factor/scatter factor, which triggers dispersal and migration of cells in monolayer culture as fibroblast-like individual cells, a mode of epithelial cell motility distinct from the collective migration of wound closure
Watanabe et al., Mol Cancer Res 2006 (Sarcoma, Synovial) : Importantly, the elimination of Crk in these cells induced the disorganization of actin cytoskeleton and complete abolishment of HGF mediated Rac1 activation and cell motility
Singleton et al., J Biol Chem 2007 (Atherosclerosis...) : In addition, silencing Tiam1 or dynamin 2 reduced HGF induced Rac1 activation , cortactin recruitment to CEM, and EC barrier regulation
Chianale et al., Mol Biol Cell 2007 : We report that specific inhibition of Dgkalpha, obtained either pharmacologically by R59949 treatment, or by expression of Dgkalpha dominant negative mutant, or by small interfering RNA mediated down-regulation of endogenous Dgkalpha, impairs 1 ) HGF- and v-Src induced cell scatter and migration, without affecting the loss of intercellular adhesions ; 2 ) HGF induced cell spreading, lamellipodia formation, membrane ruffling, and focal adhesions remodeling ; and 3 ) HGF induced Rac activation and membrane targeting
Mohamadnejad et al., Hepatology 2010 : This results in inhibition of cytosolic calcium signaling and down-regulation of HGF induced Rac1
Chianale et al., Proc Natl Acad Sci U S A 2010 : Diacylglycerol kinase alpha mediates HGF induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI
Castillo-Lluva et al., Nat Cell Biol 2010 : Here, we identify that the small ubiquitin-like modifier ( SUMO ) E3-ligase, PIAS3, interacts with Rac1 and is required for increased Rac activation and optimal cell migration in response to hepatocyte growth factor (HGF) signalling
Castillo-Lluva et al., Oncogene 2013 : We show that HACE1 and Rac1 interaction is enhanced by hepatocyte growth factor (HGF) signalling, a Rac activator and potent stimulus of cell migration
Attar et al., BMC cell biology 2013 : We now have found that Rac activation in response to hepatocyte growth factor (HGF) requires cytohesin 2 and Dock180 ... Furthermore, we find that knockdown of GRASP impairs hepatocyte growth factor (HGF) stimulated Rac activation and HGF stimulated epithelial migration
Hu et al., Cell Signal 2013 (Carcinoma, Hepatocellular...) : HGF also induced fluctuant PKC activation and Rac degradation