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ORC1 — PCNA
Text-mined interactions from Literome
Findeisen et al., Eur J Biochem 1999
:
Cyclin A-dependent kinase activity
affects chromatin binding of
ORC , Cdc6, and MCM in egg extracts of Xenopus laevis ... High
cyclin E kinase activity
allows the binding of Xenopus
ORC and Cdc6, but not MCM, to sperm chromatin, even though the kinase does not phosphorylate MCM directly
Hossain et al., Genes Dev 2012
(Growth Disorders...) :
A cyclin binding motif (Cy motif) is required for
Orc1 to bind Cyclin A and
inhibit Cyclin A-CDK2 kinase activity but has no effect on Cyclin E-CDK2 kinase activity ... In contrast,
Orc1 inhibition of
Cyclin E-CDK2 kinase activity occurs by a different mechanism that is affected by Orc1 mutations identified in Meier-Gorlin syndrome patients