Raya et al., Genes Dev 2003
(Situs Inversus) :
Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos
Kikuchi et al., Dev Dyn 2004
:
We show that deltaC, deltaD, and notch1 are expressed in the marginal domain of blastula stage embryos and that this expression is dependent on Nodal signaling
Takeuchi et al., Proc Natl Acad Sci U S A 2007
:
Notch mediated induction of Nodal at the vertebrate node is a critical step in initiating left-right ( LR ) asymmetry
Hardy et al., Cancer Res 2010
(Melanoma...) :
Surprisingly, Notch4 is specifically required for expression of Nodal in aggressive cells and plays a vital role both in the balance of cell growth and in the regulation of the aggressive phenotype