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ITCH — NOTCH1

Pathways - manually collected, often from reviews:

• Reactome Reaction: NOTCH1 → ITCH (indirect_complex) Chastagner et al., PloS one 2008, McGill et al., J Biol Chem 2009, Rhyu et al., Cell 1994*
• Reactome Reaction: NOTCH1 → ITCH (reaction) Chastagner et al., PloS one 2008, McGill et al., J Biol Chem 2009, Rhyu et al., Cell 1994*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: ITCH — NOTCH1 (physical association, affinity chromatography technology) Puca et al., J Cell Sci 2013*
• IRef Biogrid Interaction: ITCH — NOTCH1 (physical association, affinity chromatography technology) Qiu et al., J Biol Chem 2000*
• IRef Hprd Interaction: ITCH — NOTCH1 (in vivo) McGill et al., J Biol Chem 2003*
• IRef Hprd Interaction: ITCH — NOTCH1 (in vitro) McGill et al., J Biol Chem 2003*
• IRef Ophid Interaction: ITCH — NOTCH1 (aggregation, confirmational text mining) McGill et al., J Biol Chem 2003*
• IRef Ophid Interaction: ITCH — NOTCH1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Matesic et al., Hum Mol Genet 2006 (Autoimmune Diseases...) : Since Notch proteins have many important functions in the immune system, we determined whether Itch regulates Notch signaling in vivo
Chastagner et al., PloS one 2008 : AIP4/Itch regulates Notch receptor degradation in the absence of ligand ... Using Itch-/- fibroblasts expressing the Notch1 receptor, we show that Itch is not necessary for Notch activation, but rather for controlling the degradation of Notch in the absence of ligand