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IL17A — NOS2
Text-mined interactions from Literome
Martel-Pelletier et al., Arthritis Rheum 1999
(Osteoarthritis) :
Further, we explored the major intracellular signaling pathways through which
IL-17 induced
iNOS expression and NO production
Miljkovic et al., Cell Mol Life Sci 2003
:
The
effect of
interleukin (IL)-17 on the activation of
inducible nitric oxide (NO) synthase ( iNOS ) and subsequent production of NO was investigated ... The expression of iNOS transcription factor IRF-1 was also induced by IL-17 and blocked by all three inhibitors, suggesting that the
induction of
iNOS by
IL-17 might be partly exerted through IRF-1 activation
Miljkovic et al., Cytokine Growth Factor Rev 2004
(Inflammation...) :
Here we discuss the
role of
IL-17 in the cytokine network controlling
iNOS expression, and analyze signaling pathways employed by IL-17 for the initiation of iNOS gene transcription
Miljkovic et al., Cell Mol Life Sci 2005
(Diabetes Mellitus, Experimental) :
IL-17 markedly
augmented iNOS mRNA/protein expression and subsequent NO production induced in MIN6 cells or pancreatic islets by different combinations of interferon-gamma, tumor necrosis factor-alpha, and IL-1beta ... The
induction of
iNOS by
IL-17 was preceded by phosphorylation of p38 mitogen activated protein kinase ( MAPK ), and inhibition of p38 MAPK activation completely abolished IL-17 stimulated NO release
Nath et al., J Immunol 2009
(Chronic Disease...) :
It also attenuated IFN-gamma and
IL-17 induced
iNOS and cyclooxygenase 2 expression in RAW267.4 cells, further supporting its anti-inflammatory property
Yang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2011
:
[ Effect of curcumin on
IL-17 induced nitric oxide production and expression of
iNOS in human keratinocytes ] ...
IL-17 increased NO levels, and expression of
iNOS in HaCaT cells ( P < 0.01 ) ... Curcumin decreased
IL-17 induced NO production and the
iNOS expression at mRNA ( P < 0.01 ) and protein ( P < 0.01 ) levels significantly ... Curcumin down-regulates
IL-17 induced NO secretions and
iNOS expression in HaCaT cells, thus provides a theoretical basis for the treatment of inflammatory diseases of skin related to keratinocytes
Liu et al., J Immunol 2012
(Vascular Diseases) :
Induction of endothelial
nitric oxide synthase expression by
IL-17 in human vascular endothelial cells : implications for vascular remodeling in transplant vasculopathy
Obermajer et al., J Exp Med 2013
:
Inhibition of
NOS2 or cGMP-cGK signaling abolishes the de novo induction of Th17 cells and selectively
suppresses IL-17 production by established Th17 cells isolated from OvCa patients