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MAPK3 — NQO1
Text-mined interactions from Literome
Lien et al., Histol Histopathol 2008
(Prostatic Neoplasms) :
Blocking the enzyme activity of NQO1 with dicoumarol, a known
NQO1 inhibitor, or preventing an increase in intracellular calcium levels using BAPTA-AM, an intracellular calcium chelator, substantially
inhibited MAPK phosphorylation, abolished the activation of calpain, caspase-12 and caspase-7, and provided significant protection of beta-lapachone treated cells
Yang et al., In Vivo 2013
:
Molecularly,
4-NQO inhibited Rarß2 but induced expression of phosphorylated
extracellular-signal regulated kinase-1 and -2 ( p-ERK1/2 ) and Cox2 proteins and Rarß2 gene promoter methylation in murine tumors