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LOX — MAPK3
Text-mined interactions from Literome
de Bernardo et al., J Neurochem 2004
:
MEK-1/2 and
lipoxygenase (LOX) inhibitors, as well as ascorbic acid,
prevent ERK-1/2 activation and neuronal loss, but the inhibition of nitric oxide sintase (NOS), cyclo-oxygenase (COX), c-Jun N-terminal kinase (JNK) and p38 mitogen activated protein kinase ( p38 MAPK ) does not have protective effects
Zhang et al., J Neurosci 2004
:
Inhibition of
12-LOX blocked the activation of p38
MAPK and caspase-3
Voloshenyuk et al., Cytokine 2011
(MAP Kinase Signaling System) :
Induction of cardiac fibroblast
lysyl oxidase by TGF-ß1
requires PI3K/Akt, Smad3, and
MAPK signaling ... The increase of
LOX protein in response to TGF-ß1 was
prevented by inhibitors of PI3K, Smad3,
p38-MAPK , JNK and ERK1/2