Purwana et al., Biol Reprod 2011
(MAP Kinase Signaling System) :
Serum response factor (Srf) promoter activities induced by MAP3K1 were also prevented by DUSP1 overexpression, confirming that MAPK3/1 has an important role in gonadotropin subunit gene expression
Jin et al., Dev Biol 2013
:
Second, MAP3K1 potentiated AP-2a expression and SRF and AP-1 activity, but its target genes were enriched for binding motifs of AP-2a and SRF, and not AP-1, suggesting the existence of novel MAP3K1-AP-2a/SRF modules in gene regulation