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MAP3K1 — NFKBIA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: NFKBIA → MAP3K1 (directlyIncreases, NFKBIA Activity) Lee et al., Proc Natl Acad Sci U S A 1998
  Evidence: We have previously shown that mitogen-activated protein kinase/ERK kinase kinase 1 (MEKK1) can induce both this site-specific phosphorylation of IkappaB alpha at Ser-32 and Ser-36 in vivo and the activity of a high molecular weight IkappaB kinase complex in vitro.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: NFKBIA — MAP3K1 (direct interaction, enzymatic study) Tu et al., J Biol Chem 2003*

Text-mined interactions from Literome

Li et al., Biochem Biophys Res Commun 2001 : Further analysis demonstrates that although Tat alone lacks direct effect on IkappaBalpha degradation or dissociation from NF-kappaB, Tat can substantially enhance the capacity of NF-kappaB inducing kinase (NIK), but not MEKK1 , to accelerate degradation of IkappaB
Lee et al., Cell 1997 : Activation of the IkappaB alpha kinase complex by MEKK1 , a kinase of the JNK pathway ... Here, we show that MEKK1 induces the site-specific phosphorylation of IkappaB alpha in vivo and, most strikingly, can directly activate the IkappaB alpha kinase complex in vitro
Yin et al., Cell 1998 : Furthermore, recombinant MEKK1 stimulates IKKbeta phosphorylation of IkappaB alpha ... Thus, Tax mediated increases in NF-kappaB nuclear translocation result from direct interactions of Tax and MEKK1 leading to enhanced IKKbeta phosphorylation of IkappaB alpha
Wang et al., Clin Cancer Res 1999 (Adenocarcinoma...) : I kappa B alpha , a previously identified NF-kappa B-inducible gene, was overexpressed in human pancreatic tumor tissues and cell lines, and RelA activation could be inhibited by curcumin and dominant negative mutants of I kappa B alpha, raf, and MEKK1