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IL6 — S100A12

Text-mined interactions from Literome

Tang et al., Immunology 1999 : Since the nitric oxide ( NO ) and prostaglandins (PGs) induced by LPS might modulate IL-6 release, we examined whether NO and PGs were also involved in the potentiating effect of rat CGRP ( rCGRP ) on LPS induced IL-6 release from mouse macrophages
Liu et al., Immunology 2000 : Previously we showed that calcitonin gene related peptide (CGRP) , a neuropeptide, inhibited lipopolysaccharide (LPS) induced tumour necrosis factor-alpha (TNF-alpha) production and increased interleukin (IL)-6 release at low concentrations via activation of the cAMP pathway in mouse peritoneal macrophages ( Mphi )
Raap et al., J Rheumatol 2000 (Arthritis, Rheumatoid...) : In RA fibroblasts, CGRP increased IL-6 and IL-8 secretion at 10 ( -10 ) to 10 ( -8 ) M ( p at least < 0.01 ), which was not observed in OA fibroblasts
Fernandez et al., Cell Immunol 2001 : We recently found that CGRP induces IL-6 and TNF-alpha in long-term bone marrow cultures and that IL-6 and TNF-alpha also inhibit IL-7 responses ... To determine whether bone marrow derived macrophages ( BMDM ) were the source, we did studies to determine whether BMDMs express mRNAs for CGRP receptors and whether CGRP induces c-fos, IL-6 , and TNF-alpha mRNA ... CGRP also stimulated dose- and time dependent increases in c-fos and IL-6 ... These results suggest that BMDMs are a source of CGRP induced IL-6 in bone marrow
Cuesta et al., Neurochem Int 2002 : We found that substance P ( SP ) and calcitonin gene related peptide (CGRP) ( 0.3-1 microM ) increased , in a concentration dependent manner, the basal secretion of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) , and tumor necrosis factor alpha (TNF alpha) from cultured lymphocyte enriched mononuclear cells isolated from human peripheral blood
Hasegawa et al., Atherosclerosis 2003 (MAP Kinase Signaling System) : These results indicate the production of EN-RAGE is induced by IL-6 through de novo protein synthesis via the JAK-STAT kinase pathway and inhibited by the activation of peroxisome proliferator activated receptor-gamma ( PPARgamma ) in human macrophages
Fernandez et al., Cell Immunol 2003 : CGRP induction of IL-6 and TNF-alpha mRNA in long-term bone marrow cultures is transient and IL-6 or TNF-alpha inhibit IL-7 induced colony formation by 60 %
Ma et al., J Neurochem 2006 (Disease Models, Animal...) : The aim of this study was to determine if CGRP in injured nerves is involved in the up-regulation of IL-6 and in the maintenance of neuropathic pain ... Taken together, these data show that increased levels of CGRP in injured neuroma and invading macrophages are involved in the up-regulation of IL-6 in macrophages as well as in the maintenance of neuropathic pain
Wang et al., FASEB J 2009 (MAP Kinase Signaling System) : In the present study, we demonstrate that CGRP is involved in morphine tolerance by differentially regulating the ERK dependent up-regulation of IL-1beta, TNF-alpha, and microsomal prostaglandin E synthase-1 ( mPGES-1 ) in astrocytes and p38 dependent up-regulation of IL-6 in microglia in the rat spinal cord
Abbas et al., Stroke 2012 (Carotid Artery Diseases...) : Our main findings were : ( 1 ) plasma levels of S100A12 were significantly higher in patients with carotid atherosclerosis compared with healthy control subjects with the highest levels in patients with the most recent symptoms ( ie, within 2 months ) ; ( 2 ) plasma levels of S100A8/S100A9 showed a modest increase in patients with symptoms in the previous 2 to 6 months but not in the other patients ; ( 3 ) mRNA levels of S100A8, S100A9, and S100A12 showed increased expression in atherosclerotic carotid plaques from patients with the most recent symptoms compared with the remaining patients ; ( 4 ) in THP-1 monocytes, activation of Toll-like receptors 2 and 4 increased mRNA levels of S100A8, S100A9, and S10012 and interleukin-1ß , interferon ?, and releasate from thrombin activated platelets significantly enhanced the expression of S100A12
Chung et al., PloS one 2013 (Inflammation) : S100A12 did not stimulate IL-6 , IL-8, IL-1ß or TNF-a production by human peripheral blood mononuclear cells but low amounts consistently reduced cytokine mRNA and protein levels induced by serum amyloid A, by ~49 % and ~46 %, respectively
Sakuta et al., Cell Immunol 1995 : A kinetic study of IL-6 activity in the culture supernatant showed that CGRP not only accelerated but also increased IL-6 production ... Enhancement by CGRP of cytokine dependent IL-6 production was ascribed to the increased accumulation of IL-6 mRNA
Sakagami et al., J Bone Miner Res 1993 : CGRP , however, did not affect cAMP or IL-6 in the rat osteogenic sarcoma cell line UMR-106-06, which exhibits CT receptors, whereas CT stimulated both cAMP and IL-6 by the UMR-106-01 cells ... These data suggest that bone marrow derived stromal cells express receptors for either CGRP or PTH in a phenotype-specific manner and that, acting via these receptors, CGRP and PTH stimulate IL-6 production by stromal cells ... In addition, the evidence for specific receptors for the neuropeptide CGRP in bone marrow stromal cells and an effect of CGRP on IL-6 raises the possibility for a role of cytokines in a putative interplay between neuronal stimuli and bone
Kiriyama et al., J Neuroimmunol 1997 (Glioblastoma) : Human CT and human CGRP increased IL-6 production and cAMP accumulation in a dose dependent manner ... A specific protein kinase A inhibitor, H-89, inhibited both CT- and CGRP induced IL-6 production ... CGRP ( 8-37 ), a specific CGRP receptor inhibitor, inhibited cAMP accumulation and IL-6 production induced by CGRP, but did not inhibit these effects when they were induced by CT. Salmon CT ( 8-32 ), a specific inhibitor of the CT receptor, inhibited cAMP accumulation induced by CT, but did not inhibit the effect induced by CGRP
Tang et al., J Neuroimmunol 1998 : Since calcitonin gene related peptide (CGRP) is known to increase cAMP accumulation in mouse macrophages, we examined whether CGRP would induce IL-6 release in macrophages ... The results showed that CGRP had no direct effects on IL-6 production, but it potentiated LPS induced IL-6 production in a concentration dependent manner ... These results demonstrate that the LPS induced IL-6 release is potentiated by CGRP via the activation of cAMP pathway in mouse resident peritoneal macrophages