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IL6 — MYLIP

Text-mined interactions from Literome

Meng et al., Oncogene 2008 (Bile Duct Neoplasms...) : Overexpression of IL-6 reduced miR-370 expression and reinstated MAP3K8 expression in vitro as well as in tumor cell xenografts in vivo
Stanczyk et al., Arthritis Rheum 2008 (Arthritis, Rheumatoid) : Constitutive expression of both miR-155 and miR-146a was higher in RASFs than in those from patients with osteoarthritis ( OA ), and expression of miR-155 could be further induced by TNFalpha, interleukin-1beta , lipopolysaccharide, poly ( I-C ), and bacterial lipoprotein
Brock et al., Circ Res 2009 (Carcinoma, Hepatocellular...) : Because IL-6 signaling is mainly mediated by STAT3 ( signal transducer and activator of transcription 3 ), the expression of STAT3 was knocked down by small interfering RNA, which abolished the IL-6 mediated expression of miR-17/92
Bhaumik et al., Aging 2009 : Indeed, ectopic expression of miR-146a/b in primary human fibroblasts suppressed IL-6 and IL-8 secretion and downregulated IRAK1, a crucial component of the IL-1 receptor signal transduction pathway
Larner-Svensson et al., Respir Res 2010 : Functional studies indicated that IL-1beta induced miR-146a expression does not negatively regulate IL-6 and IL-8 release or basal proliferation ... Unlike previous reports, studies using miRNA inhibitors showed that miR-146a expression did not regulate IL-6 and IL-8 release or proliferation and suggest miR-146a function and mechanism is cell-type dependent
Majid et al., Cancer 2010 (Neoplasm Invasiveness...) : In this study, the authors demonstrated that miRNA-205 (miR-205) induced the expression the interleukin ( IL ) tumor suppressor genes IL24 and IL32 by targeting specific sites in their promoters
Stanczyk et al., Arthritis Rheum 2011 (Arthritis, Rheumatoid...) : Enforced expression of miR-203 led to significantly increased levels of MMP-1 and IL-6 ... Induction of IL-6 by miR-203 overexpression was inhibited by blocking of the NF-?B pathway
Meng et al., J Cell Mol Med 2012 (Carcinoma, Hepatocellular...) : Knocking down IL-6 and Twist in HSCs significantly reduced let-7 and miR-181 expression and subsequently inhibited chemoresistance and cell invasion
Sun et al., Blood 2011 (Sepsis) : In vitro knockdown and overexpression studies demonstrated a critical and specific role for miR142-3p in regulating IL-6 production by the DCs after LPS stimulation
Xu et al., J Biol Chem 2011 : miR-365 , a novel negative regulator of interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-kappaB ... Furthermore, miR-365 exhibited a greater negative regulatory effect on IL-6 than hsa-let-7a, a previously identified microRNA negatively regulating IL-6
Philippe et al., J Immunol 2012 (Arthritis, Rheumatoid) : Taken together, our data point toward an important role for miR-19a/b in the regulation of IL-6 and matrix metalloproteinase 3 release by controlling TLR2 expression, as well as provide evidence that miR-19a/b can act as negative regulators of inflammation in humans
Wang et al., Hepatology 2012 (Carcinoma, Hepatocellular...) : Finally, this study showed that the activation of interleukin (IL)-6-Stat3 signaling caused the up-regulation of miR-23a expression in HCC ... CONCLUSION : Based on these data, we conclude that gluconeogenesis is severely compromised in HCC by IL6-Stat3 mediated activation of miR-23a , which directly targets PGC-1a and G6PC, leading to decreased glucose production
Rokavec et al., Mol Cell 2012 (Cell Transformation, Neoplastic...) : IL6 mediated suppression of miR-200c directs constitutive activation of inflammatory signaling circuit driving transformation and tumorigenesis
Vaporidi et al., Am J Physiol Lung Cell Mol Physiol 2012 (Disease Models, Animal...) : In the inflammatory network, IL-6 and SOCS-1, regulated by miRNAs let-7 and miR-155 , respectively, appeared as central nodes
Kumar et al., Cell Microbiol 2012 : In addition, M.tb. induced miR-155 inhibits expression of cyclooxygenase-2 (Cox-2) and interleukin-6 (Il-6) , two modulators of the innate immune response
Bao et al., PloS one 2012 (Neoplasm Invasiveness...) : The treatment of PCa cells with CDF, a novel Curcumin derived synthetic analogue previously showed anti-tumor activity in vivo, inhibited the productions of VEGF and IL-6 , and down-regulated the expression of Nanog, Oct4, EZH2 mRNAs, as well as miR-21 under hypoxic condition
Wu et al., J Lipid Res 2012 (Hyperlipidemias) : Abundance of miR-181a attenuated ox-LDL induced CD83 and CD40 expression, inhibited the secretion of interleukin (IL)-6 and TNF-a, and up-regulated IL-10, an important anti-inflammatory cytokine that was inhibited by ox-LDL
Iyer et al., PloS one 2012 (Brain Diseases...) : In addition, the expression of IL-6 and COX-2 upon IL-1ß stimulation was suppressed by increased levels of miR-146a and increased by the reduction of miR-146a ... Modulation of miR-146a expression affected also the release of several cytokines such as IL-6 and TNF-a
Rossato et al., Proc Natl Acad Sci U S A 2012 (Sepsis) : Ectopic expression of miR-187 consistently and selectively reduces TNFa, IL-6 , and IL-12p40 produced by LPS activated monocytes
An et al., PloS one 2012 (Cholangiocarcinoma) : In addition, we show that IL-6 induces a time dependent silencing of miR-370 ... Our data indicate that the paternal allele of miR-370 is normally silenced through genomic imprinting and that the overexpression of IL-6 in CCA effectively suppresses the expression of miR-370 from the maternal allele, lending support to the theory that miR-370 silencing in human CCA follows a classic two-hit mechanism
Rosenberger et al., J Immunol 2012 (Melanoma, Experimental...) : miR-451 levels are themselves increased by IL-6 and type I IFN, potentially forming a regulatory loop
Wang et al., Biochem Biophys Res Commun 2013 : Bioinformatics ' miR target analysis identified homology between miR-146a and the 3'-UTR of the human IL-6 mRNA, suggesting a potential regulation of IL-6 by miR-146a
Xu et al., Mol Biol Rep 2013 (Obesity) : Tumor necrosis factor-a (TNF-a), leptin and resistin, but not interleukin-6 , caused downregulation of hsa-miR-26b expression in adipocytes
Yu et al., Cancer Res 2013 : Either miR-145 suppression or ADAM17 overexpression in non-TICs/ALDH1 ( - ) CD44 ( - ) -HNC cells increased expression and secretion of interleukin (IL)-6 and soluble-IL-6 receptor ( sIL-6R )