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ADCYAP1 — IL6

Text-mined interactions from Literome

Delgado et al., J Neuroimmunol 1999 (Endotoxemia) : VIP/PACAP inhibit the production of IL-12, IL-6 , tumor necrosis factor alpha (TNFalpha), and interferon gamma (IFNgamma) in vivo in endotoxemic mice
Delgado et al., J Neuroimmunol 1999 : We reported previously that VIP and PACAP inhibit IL-6 , IL-12, TNF alpha and NO production, and enhance IL-10 production, from lipopolysaccharide (LPS) stimulated macrophages
Delgado et al., J Biol Chem 1999 : We showed previously that VIP and PACAP inhibit the production of macrophage derived tumor necrosis factor-alpha, interleukin (IL)-6 , nitric oxide, and IL-12
Leceta et al., Ann N Y Acad Sci 2000 (Inflammation) : VIP/PACAP inhibit the production of TNF alpha, IL-6 , IL-12, and nitric oxide ( NO ), and stimulate IL-10 in peritoneal macrophages and Raw 264.7 cells
Riera et al., Transplantation 2001 (Acute Kidney Injury...) : PACAP-38 increased circulating IL-6 , and minimized renal inflammatory cell infiltration induced by ischemia-reperfusion injury, as evidenced by a reduction of MPO activity and the number of CD45+ cells in ischemic renal tissue
Delgado et al., J Leukoc Biol 2003 : VIP and PACAP inhibit TNF-alpha, IL-1beta, IL-6 , and NO production by lipopolysaccharide (LPS) activated microglia
Nagashima et al., Mol Cell Endocrinol 2003 (Pituitary Neoplasms) : Point mutations in kappaB, TRE, NF-IL-6 and CRE sites in the IL-6 promoter show that PACAP stimulates IL-6 through TRE and CRE sites ... Thus, we demonstrate that transcription factors of the CREB and AP-1 family are critical for the stimulation of IL-6 by PACAP in TtT/GF cells and that estrogens block this stimulation by inhibiting AP-1 activity
Shioda et al., Nihon Yakurigaku Zasshi 2004 (Brain Ischemia) : IL-6 secretion into the CSF was markedly stimulated after PACAP infusion, suggesting that PACAP stimulates IL-6 secretion from astrocytes
Nagakawa et al., Oncol Rep 2005 (Prostatic Neoplasms) : We performed RT-PCR analysis to assess the expression of VIP receptor ( VPAC1, VPAC2 and PAC1 ) mRNA in normal prostate epithelial and stromal cells and prostate cancer cells, and investigated the effect of VIP and PACAP on the production of IL-6
Persson et al., Biochem Biophys Res Commun 2005 : Furthermore, IL-1beta stimulated IL-6 promoter activity in the osteoblastic cell line MC3T3-E1 stably transfected with a human IL-6 promoter/luciferase construct, and both VIP, and the related neuropeptide PACAP-38 , increased the effect of IL-1beta in a synergistic manner
Zhang et al., Curr Eye Res 2005 : To examine pituitary adenylate cyclase activating polypeptide ( PACAP ) receptors ( PAC1, VPAC1, and VPAC2 ) mRNA and the effect of PACAP on interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemotactic protein-1 (MCP-1) expression in human retinal pigment epithelial cell line ( ARPE-19 ) stimulated with interleukin-1beta (IL-1beta) ... PACAP inhibited IL-6 , IL-8, and MCP-1 expression and protein secretion
Tatsuno et al., Endocrinology 1991 : Using discontinuous Percoll gradients to fractionate the pituitary cells, the greatest PACAP38 stimulated IL-6 secretion was observed in the low density fraction 1 ( F1 ) ... FS cells appear to be the most likely target cell type for PACAP induced IL-6 production ... However, IL-6 producing FS cells may not be an exclusive target for PACAP in the pituitary
Seki et al., Ann N Y Acad Sci 2006 : PACAP stimulates the release of interleukin-6 in cultured rat Müller cells ... PACAP stimulated IL-6 production in Müller cells at a concentration as low as 10 ( -12 ) M, which was not sufficient to induce cell proliferation
Li et al., Cancer Res 2006 (Multiple Myeloma) : The secretion of IL-6 by BMSCs was completely inhibited by 10 ( -9 ) mol/L PACAP , which also attenuated the phosphorylation of both p42/44 and p38 mitogen activated protein kinases ( MAPK ) as well as nuclear factor-kappaB (NF-kappaB) activation in response to the adhesion of multiple myeloma cells to BMSCs, whereas the inhibition of p42/44 MAPK signaling attenuated PACAP action
Kageyama et al., J Endocrinol 2007 : PACAP stimulated interleukin (IL)-6 promoter activity and the levels of IL-6 mRNA and protein ... Taken together, these findings indicate that PACAP stimulates the transcription of CRF, AVP, and IL-6 genes in hypothalamic 4B cells
Nagata et al., J Cell Physiol 2009 : cAMP activation by PACAP/VIP stimulates IL-6 release and inhibits osteoblastic differentiation through VPAC2 receptor in osteoblastic MC3T3 cells ... We also found that PACAP and VIP stimulated IL-6 release, a stimulator of bone resorption, and VPAC2-R silencing inhibited IL-6 production ... Thus, PACAP/VIP can activate adenylate cyclase response and regulate IL-6 release through VPAC2 receptor with profound functional consequences for the inhibition of osteoblastic differentiation in MC3T3-E1 cells
Mester et al., J Mol Neurosci 2011 : PACAP receptors have been identified on the retinal pigment epithelial cells and PACAP has been shown to inhibit interleukin secretion from pigment epithelial cells
Nakamachi et al., J Mol Neurosci 2012 (Brain Ischemia...) : These results suggest that PACAP could stimulate IL-6 secretion by neurons during the acute phase after an ischemic episode and thereafter by astrocytes during the subacute phase
Yu et al., Peptides 2012 (Body Weight...) : PACAP-TAT decreased myeloperoxidase (MPO) activity, increased catalase (CAT) activity and down-regulated interleukin 6 (IL-6) and malondialdehyde ( MDA ) levels in the lungs with a significantly higher efficiency than PACAP
Desai et al., Mol Cell Endocrinol 1994 (Choriocarcinoma...) : PACAP-38 also stimulated the production of IL-6 from JEG-3 cells with a time course of response similar to that of alpha-promoter transcription
Matsumoto et al., Endocrinology 1993 (Pituitary Neoplasms) : PACAP-38 , PACAP-27, and VIP all stimulated the release of interleukin-6 (IL-6) from TtT/GF cells ... PACAP 38 ( 10 ( -8 ) M ) stimulated IL-6 production effectively within 1 h of incubation, and the level attained at 8 h of cultivation ( 620 pg/ml ) was nearly 10-fold that in the absence of PACAP-38 ( 60 pg/ml ) ... PACAP-38 and VIP stimulated IL-6 secretion significantly at 10 ( -10 ) -10 ( -9 ) M in a bell shaped manner ; the maximum values were 10 ( -7 ) and 10 ( -8 ) M, respectively
Vigh et al., Peptides 1993 : A recent study from our laboratory demonstrated that PACAP stimulated the release of interleukin (IL)-6 in rat pituitary cell cultures
Benter et al., Exp Clin Endocrinol Diabetes 1995 : PACAP also stimulated interleukin 6 (IL6) release under each of the experimental conditions
Cai et al., Endocrinology 1997 : Both forms of PACAP , PACAP-27 and PACAP-38, as well as VIP significantly increased IL-6 production by rat BM-derived stromal cells at physiological concentrations ranging from 10 ( -10 ) -10 ( -8 ) M ... The stimulatory potency of the three related peptides for the production of IL-6, cAMP, and IP3 was almost consistent, suggesting that the dual signaling transduction pathways may be involved in PACAP/VIP induced IL-6 production in rat BM-derived stromal cells ... The results shown in this paper suggest that PACAP/VIP and their receptor play an important role in the IL-6 production and perhaps in the hematopoiesis in the BM
Martínez et al., J Leukoc Biol 1998 : We have investigated the effects of VIP and PACAP38 on the production of interleukin-6 (IL-6) , a proinflammatory cytokine, by endotoxin activated murine macrophages ... Whereas VIP and PACAP inhibit with similar dose-response curves the release of IL-6 from macrophages stimulated with a LPS dose range from 100 pg/mL to 10 microg/mL, both neuropeptides enhance IL-6 secretion in unstimulated macrophages and in macrophages stimulated with very low LPS concentrations ( 1-10 pg/mL ) ... VIP and PACAP regulate the production of IL-6 at a transcriptional level
Martinez et al., J Neuroimmunol 1998 : VIP and PACAP38 regulate the production of IL-6 at a transcriptional level, affecting the de novo synthesis of this cytokine
Delgado et al., J Immunol 1999 : Previous reports showed that VIP/PACAP inhibit IL-6 and TNF-alpha production in LPS stimulated macrophages