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CBL — GRB2

Pathways - manually collected, often from reviews:

• BioCarta cbl mediated ligand-induced downregulation of egf receptors pathway: CBL → GRB2 (protein ubiquitination, activates)
• NCI Pathway Database Signaling events mediated by Stem cell factor receptor (c-Kit): CBL/CRKL/GRB2 complex (CBL-CRKL-GRB2) → SCF/KIT complex (KITLG-KIT) (protein ubiquitination, collaborate)
  Zeng et al., Blood 2005
  Evidence: assay
• NCI Pathway Database FGF signaling pathway: GRB2/SOS1/SHC/FRS2/FGFR/FGF/Syndecan-2 complex (FRS2-SDC2-GRB2-SHC1-SOS1) → CBL (CBL) (modification, collaborate) Wong et al., Proc Natl Acad Sci U S A 2002
• NCI Pathway Database FGF signaling pathway: GRB2/SOS1/SHC/FRS2/FGFR/FGF/Syndecan-2 complex (FRS2-SDC2-GRB2-SHC1-SOS1) → FGFR/FGF/Syndecan-2/FRS2/Cbl/GRB2/SOS1/SHC complex (SDC2-FRS2-CBL-GRB2-SHC1-SOS1) (modification, collaborate)
  Wong et al., Proc Natl Acad Sci U S A 2002
• NCI Pathway Database FGF signaling pathway: CBL (CBL) → FGFR/FGF/Syndecan-2/FRS2/Cbl/GRB2/SOS1/SHC complex (SDC2-FRS2-CBL-GRB2-SHC1-SOS1) (modification, collaborate)
  Wong et al., Proc Natl Acad Sci U S A 2002
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/GRB2/CBL complex (EGFR-EGF-GRB2-CBL) → EGFR/EGFR/EGF/EGF complex (EGFR-EGF) (modification, collaborate)
  
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/GRB2/CBL complex (EGFR-EGF-GRB2-CBL) → GRB2/CBL complex (GRB2-CBL) (modification, collaborate)
  
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF complex (EGFR-EGF) → GRB2/CBL complex (GRB2-CBL) (modification, collaborate)
  
• NCI Pathway Database Signaling events mediated by Stem cell factor receptor (c-Kit): GRB2 (GRB2) → CBL/CRKL/GRB2 complex (CBL-CRKL-GRB2) (modification, collaborate)
  Brizzi et al., Oncogene 1996
  Evidence: assay
• NCI Pathway Database Signaling events mediated by Stem cell factor receptor (c-Kit): GRB2 (GRB2) → CBL/CRKL complex (CBL-CRKL) (modification, collaborate)
  Brizzi et al., Oncogene 1996
  Evidence: assay
• NCI Pathway Database Signaling events mediated by Stem cell factor receptor (c-Kit): CBL/CRKL/GRB2 complex (CBL-CRKL-GRB2) → CBL/CRKL complex (CBL-CRKL) (modification, collaborate)
  Brizzi et al., Oncogene 1996
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF complex (EGFR-EGF) → EGFR/EGFR/EGF/EGF/GRB2/CBL complex (EGFR-EGF-GRB2-CBL) (modification, collaborate)
  Levkowitz et al., Mol Cell 1999, Waterman et al., EMBO J 2002, Jiang et al., Mol Biol Cell 2003*, Jiang et al., Traffic 2003*, Huang et al., Mol Biol Cell 2005, Huang et al., Proc Natl Acad Sci U S A 2007*
  Evidence: physical interaction
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF complex (EGFR-EGF) → GRB2/CBL complex (GRB2-CBL) (modification, collaborate)
  Levkowitz et al., Mol Cell 1999, Waterman et al., EMBO J 2002, Jiang et al., Mol Biol Cell 2003*, Jiang et al., Traffic 2003*, Huang et al., Mol Biol Cell 2005, Huang et al., Proc Natl Acad Sci U S A 2007*
  Evidence: physical interaction
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/GRB2/CBL complex (EGFR-EGF-GRB2-CBL) → GRB2/CBL complex (GRB2-CBL) (modification, collaborate)
  Levkowitz et al., Mol Cell 1999, Waterman et al., EMBO J 2002, Jiang et al., Mol Biol Cell 2003*, Jiang et al., Traffic 2003*, Huang et al., Mol Biol Cell 2005, Huang et al., Proc Natl Acad Sci U S A 2007*
  Evidence: physical interaction
• Reactome Reaction: CBL → GRB2 (direct_complex) Rosenthal et al., J Biol Chem 1999, Soubeyran et al., Nature 2002, Kassenbrock et al., J Biol Chem 2004, Dufour et al., Bone 2008, Odai et al., J Biol Chem 1995, Galisteo et al., J Biol Chem 1995*, Panchamoorthy et al., J Biol Chem 1996, Anderson et al., J Biol Chem 1997, Hunter et al., Mol Endocrinol 1997, Feshchenko et al., J Biol Chem 1998, Park et al., J Immunol 1998
• Reactome Reaction: CBL → GRB2 (reaction) Joazeiro et al., Science 1999, Rao et al., J Leukoc Biol 2002*, Wong et al., Proc Natl Acad Sci U S A 2002, Wollberg et al., Biochem J 2003, Fong et al., J Biol Chem 2003, Marmor et al., Oncogene 2004, Kassenbrock et al., J Biol Chem 2004, Masson et al., Biochem J 2006*, Sun et al., Exp Cell Res 2007, Odai et al., J Biol Chem 1995, Galisteo et al., J Biol Chem 1995*, Panchamoorthy et al., J Biol Chem 1996, Anderson et al., J Biol Chem 1997, Hunter et al., Mol Endocrinol 1997, Feshchenko et al., J Biol Chem 1998, Park et al., J Immunol 1998
• Reactome Reaction: CBL → GRB2 (indirect_complex) Rao et al., J Leukoc Biol 2002*, Wollberg et al., Biochem J 2003, Masson et al., Biochem J 2006*, Sun et al., Exp Cell Res 2007

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: GRB2 — CBL Wong et al., J Biol Chem 2001
• IRef Bind Interaction: GRB2 — CBL Meisner et al., Mol Cell Biol 1995*, Buday et al., J Biol Chem 1996*
• IRef Bind_translation Interaction: CBL — GRB2 (fluorescent resonance energy transfer) Galperin et al., Nat Methods 2004*
• IRef Bind_translation Interaction: GRB2 — CBL (experimental interaction detection) Meisner et al., Mol Cell Biol 1995*
• IRef Bind_translation Interaction: GRB2 — CBL (affinity chromatography technology) Wong et al., J Biol Chem 2001
• IRef Bind_translation Interaction: GRB2 — CBL (affinity chromatography technology) Meisner et al., Mol Cell Biol 1995*, Buday et al., J Biol Chem 1996*
• IRef Bind_translation Interaction: GRB2 — CBL (coimmunoprecipitation) Meisner et al., Mol Cell Biol 1995*
• IRef Bind_translation Interaction: GRB2 — CBL (coimmunoprecipitation) Meisner et al., Mol Cell Biol 1995*, Buday et al., J Biol Chem 1996*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Chu et al., Blood 1998*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Wang et al., J Cell Biochem 1999
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Bonita et al., Mol Cell Biol 1997*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Meisner et al., Mol Cell Biol 1995*
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, far western blotting) Meisner et al., Mol Cell Biol 1995*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Barber et al., Blood 1997*
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, pull down) Shishido et al., Proc Natl Acad Sci U S A 2000*
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, far western blotting) Bartkiewicz et al., J Biol Chem 1999*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Tarcic et al., Curr Biol 2009*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Belleudi et al., Traffic 2007*
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, pull down) Brizzi et al., Oncogene 1996
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Brenner et al., Biochem Biophys Res Commun 2001*
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, pull down) Huang et al., Mol Immunol 2000*
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, pull down) Donovan et al., J Biol Chem 1996*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Hunter et al., Mol Endocrinol 1997
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, pull down) Gaston et al., Exp Hematol 2004*
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, two hybrid) Gaston et al., Exp Hematol 2004*
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, pull down) Tsygankov et al., J Biol Chem 1996*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Levkowitz et al., Oncogene 1996*
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, pull down) Jain et al., Oncogene 1997*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Donovan et al., J Biol Chem 1996*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Liu et al., J Biol Chem 1997*
• IRef Biogrid Interaction: CBL — GRB2 (association, biochemical) Odai et al., J Biol Chem 1995
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Odai et al., J Biol Chem 1995
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Meisner et al., J Biol Chem 1995*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Scott et al., J Biol Chem 2005*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Selbach et al., Nat Methods 2006
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, pull down) Yokouchi et al., Oncogene 1997*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Panchamoorthy et al., J Biol Chem 1996
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Fukazawa et al., J Biol Chem 1995*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Oda et al., Blood 1996*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Buday et al., J Biol Chem 1996*
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, pull down) Fukazawa et al., J Biol Chem 1995*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Cerboni et al., Eur J Immunol 1998*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Anderson et al., J Biol Chem 1997
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, pull down) Fixman et al., J Biol Chem 1997*
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, pull down) Houtman et al., Nature structural & molecular biology 2006*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Brizzi et al., Oncogene 1996
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, pull down) Fukazawa et al., J Biol Chem 1996
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Bisson et al., Nat Biotechnol 2011
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Fukazawa et al., J Biol Chem 1996
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Boussiotis et al., Science 1997*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Jain et al., Oncogene 1997*
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, pull down) Liu et al., Oncogene 1998
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Ettenberg et al., Oncogene 1999*
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, pull down) Donovan et al., J Biol Chem 1994*
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, pull down) Wong et al., Proc Natl Acad Sci U S A 2002
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Wong et al., Proc Natl Acad Sci U S A 2002
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, two hybrid) Robertson et al., Biochem Biophys Res Commun 1997*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Erdreich-Epstein et al., J Leukoc Biol 1999*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Park et al., J Immunol 1999*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Gesbert et al., J Biol Chem 1998*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Erdreich-Epstein et al., Exp Cell Res 1997*
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, pull down) Odai et al., Blood 1997
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Saci et al., Biochem J 2002*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Husson et al., Oncogene 1997*
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, pull down) Gesbert et al., J Biol Chem 1998*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Ng et al., EMBO J 2008
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Khan et al., FASEB J 2008*
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, two hybrid) Bandyopadhyay et al., Nat Methods 2010
• IRef Biogrid Interaction: CBL — GRB2 (direct interaction, fluorescent resonance energy transfer) Jiang et al., Traffic 2003*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Waterman et al., EMBO J 2002
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Miraoui et al., Hum Mol Genet 2010*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Ingham et al., J Biol Chem 1996*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Ravid et al., J Biol Chem 2004
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Izadi et al., Exp Cell Res 1998*
• IRef Biogrid Interaction: CBL — GRB2 (physical association, affinity chromatography technology) Rellahan et al., Exp Cell Res 2003
• MIPS CORUM CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1): CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1) complex (BCAR1-CBL-CRK-GRB2-PIK3R1-SH3KBP1-SOS1) Watanabe et al., Biochem Biophys Res Commun 2000
• MIPS CORUM LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 signaling complex, C305 activated: LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 signaling complex, C305 activated complex (CBL-GRB2-LAT-LCP2-PIK3R1-PLCG1-VAV1) Zhang et al., Cell 1998
• MIPS CORUM Cbl-SLP-76-Grb2 complex, Fc receptor gamma-R1 stimulated: Cbl-SLP-76-Grb2 complex, Fc receptor gamma-R1 stimulated complex (CBL-GRB2-LCP2) Chu et al., Blood 1998*
• MIPS CORUM SLP-76-Cbl-Grb2-Shc complex, Fc receptor gamma-R1 stimulated: SLP-76-Cbl-Grb2-Shc complex, Fc receptor gamma-R1 stimulated complex (CBL-GRB2-LCP2-SHC1) Chu et al., Blood 1998*
• MIPS CORUM EGFR-CBL-GRB2 complex: EGFR-CBL-GRB2 complex complex (CBL-EGFR-GRB2) Galperin et al., Nat Methods 2004*
• IRef Corum Interaction: Complex of CBL-SHC1-GRB2-LCP2 (association, coimmunoprecipitation) Chu et al., Blood 1998*
• IRef Corum Interaction: Complex of CBL-GRB2-LCP2 (association, coimmunoprecipitation) Chu et al., Blood 1998*
• IRef Corum Interaction: Complex of EGFR-CBL-GRB2 (association, fluorescent resonance energy transfer) Galperin et al., Nat Methods 2004*
• IRef Corum Interaction: Complex of LCP2-GRB2-PIK3R1-CBL-LAT-PLCG1-VAV1 (association, coimmunoprecipitation) Zhang et al., Cell 1998
• IRef Corum Interaction: Complex of SH3KBP1-SOS1-PIK3R1-GRB2-CBL-BCAR1-CRK (association, coimmunoprecipitation) Watanabe et al., Biochem Biophys Res Commun 2000
• IRef Dip Interaction: GRB2 — CBL (direct interaction, isothermal titration calorimetry) Houtman et al., Nature structural & molecular biology 2006*
• IRef Hprd Interaction: CBL — GRB2 (in vitro) Lin et al., Int Immunol 2001*, Saci et al., Biochem J 2002*, Gaston et al., Exp Hematol 2004*, Houtman et al., Nature structural & molecular biology 2006*, Ng et al., EMBO J 2008, Motto et al., J Biol Chem 1994*, Smit et al., J Biol Chem 1996, Hendricks-Taylor et al., J Biol Chem 1997, Duborjal et al., FEBS Lett 1997*, Jagielski et al., Pol Przegl Radiol Med Nukl 1977*, Bonita et al., Mol Cell Biol 1997*, Kanda et al., Eur J Immunol 1997*
• IRef Hprd Interaction: CBL — GRB2 (in vivo) Lin et al., Int Immunol 2001*, Saci et al., Biochem J 2002*, Gaston et al., Exp Hematol 2004*, Houtman et al., Nature structural & molecular biology 2006*, Ng et al., EMBO J 2008, Motto et al., J Biol Chem 1994*, Smit et al., J Biol Chem 1996, Hendricks-Taylor et al., J Biol Chem 1997, Duborjal et al., FEBS Lett 1997*, Jagielski et al., Pol Przegl Radiol Med Nukl 1977*, Bonita et al., Mol Cell Biol 1997*, Kanda et al., Eur J Immunol 1997*
• IRef Hprd Interaction: Complex of GRB2-RET-CBL-RET-GRB2-CBL-CBL-RET-GRB2 (in vivo) Scott et al., J Biol Chem 2005*
• IRef Hprd Interaction: Complex of ABL1-GRB2-CBL-GRB2-CBL-CBL-ABL1-GRB2-ABL1 (in vivo) Gaston et al., Exp Hematol 2004*
• IRef Hprd Interaction: Complex of CBL-GRB2-LCP2-LCP2-LCP2-GRB2-CBL-CBL-GRB2 (in vivo) Chu et al., Blood 1998*
• IRef Hprd Interaction: Complex of GRB2-CBL-PIK3R1-CBL-GRB2-PIK3R1-PIK3R1-GRB2-CBL (in vivo) Fukazawa et al., J Biol Chem 1995*
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Chu et al., Blood 1998*
• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Selbach et al., Nat Methods 2006
• IRef Intact Interaction: Complex of 15 proteins (association, anti bait coimmunoprecipitation) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Intact Interaction: GRB2 — CBL (physical association, pull down) Scott et al., J Biol Chem 2005*
• IRef Intact Interaction: GRB2 — CBL (physical association, anti tag coimmunoprecipitation) Scott et al., J Biol Chem 2005*
• IRef Intact Interaction: GRB2 — CBL (physical association, competition binding) Sanjay et al., FEBS J 2006*
• IRef Intact Interaction: GRB2 — CBL (physical association, anti bait coimmunoprecipitation) Ng et al., EMBO J 2008
• IRef Intact Interaction: GRB2 — CBL (physical association, two hybrid pooling approach) Bandyopadhyay et al., Nat Methods 2010
• IRef Intact Interaction: GRB2 — CBL (physical association, anti bait coimmunoprecipitation) Fukazawa et al., J Biol Chem 1995*
• IRef Intact Interaction: GRB2 — CBL (physical association, pull down) Fukazawa et al., J Biol Chem 1995*
• IRef Intact Interaction: GRB2 — CBL (physical association, anti tag coimmunoprecipitation) Fukazawa et al., J Biol Chem 1995*
• IRef Intact Interaction: Complex of UBASH3B-SHC1-PCCB-MCCC2-GRB2-INPPL1-CBL-PIK3R1-PIK3R2 (association, tandem affinity purification) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Intact Interaction: Complex of CBL-SPRY2-GRB2 (association, anti bait coimmunoprecipitation) Lao et al., J Biol Chem 2006
• IRef Intact Interaction: Complex of 28 proteins (association, tandem affinity purification) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Intact Interaction: Complex of 70 proteins (association, anti bait coimmunoprecipitation) Thelemann et al., Mol Cell Proteomics 2005
• IRef Intact Interaction: Complex of 13 proteins (association, tandem affinity purification) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Intact Interaction: Complex of 29 proteins (association, tandem affinity purification) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Intact Interaction: Complex of 37 proteins (association, tandem affinity purification) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Intact Interaction: Complex of 17 proteins (association, anti bait coimmunoprecipitation) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Intact Interaction: Complex of 12 proteins (association, tandem affinity purification) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Ophid Interaction: GRB2 — CBL (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Take et al., Biochem Biophys Res Commun 2000 : Our results suggest that CIN85 may play a specific role in the EGF receptor mediated signaling cascade via its interaction with c-Cbl
Petrelli et al., Nature 2002 : Cbl, in turn, binds and ubiquitinates activated HGF receptor , and by recruiting the endophilin-CIN85 complex , it regulates receptor internalization
Kowanetz et al., J Biol Chem 2003 : Identification of a novel proline-arginine motif involved in CIN85 dependent clustering of Cbl and down-regulation of epidermal growth factor receptors
Gaston et al., Exp Hematol 2004 : In a yeast three-hybrid assay, Grb2 mediated an interaction between Cbl and Bcr-Abl that was dependent on a functional Grb2 binding site ... Grb2 or another, yet unidentified, protein may mediate an initial interaction between Cbl and Bcr-Abl that is independent of Cbl tyrosine phosphorylation
Grøvdal et al., Exp Cell Res 2004 : Collectively, these data suggest that the ubiquitination resulting from direct binding of Cbl to pTyr1045 of the EGFR is critical for lysosomal sorting of the EGFR in contrast to ubiquitination resulting from Grb2 mediated binding of Cbl to the EGFR
Peruzzi et al., J Immunol 2007 (Calcium Signaling) : We found that CIN85 overexpression inhibits the FcepsilonRI induced tyrosine phosphorylation of phospholipase Cgamma , thus altering calcium mobilization ... Altogether, our findings support a new role for CIN85 in regulating Syk protein levels in RBL-2H3 cells through the activation of the ubiquitin-proteasome pathway and provide a mechanism for this regulation involving c-Cbl ligase activity
Wakasaki et al., Neoplasia (New York, N.Y.) 2010 (Carcinoma, Squamous Cell...) : Little is known, however, about a role of CIN85 in EGFR signaling as well as its relevance to tumor development and progression of HNSCC
Marois et al., J Biol Chem 2011 : Silencing the expression of CIN85 by siRNA in dibutyryl cyclic AMP differentiated PLB 985 cells prevented Fc?RIIa degradation and increased IgG mediated phagocytosis
Tossidou et al., Mol Cell Biol 2012 : Our results indicate a novel role for CD2AP in regulating posttranslational modification of CIN85
Samoylenko et al., Carcinogenesis 2012 (Adenocarcinoma...) : Thereby, Ruk ( l ) /CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of Src , Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility ... Thereby, Ruk ( l ) /CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of Src, Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility ... Thereby, Ruk ( l ) /CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of Src, Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility
Schroeder et al., Mol Biol Cell 2012 : In this study we show that EGFR activation leads to a pronounced src mediated tyrosine phosphorylation of CIN85 that subsequently influences EGFR ubiquitination
Bior et al., FEBS Lett 2013 : Dab1 stabilizes its interaction with Cin85 by suppressing Cin85 phosphorylation at serine 587 ... Furthermore a Cin85 Ser587 phosphomimetic disrupts the Dab1-Cin85 complex without affecting the Cin85-CapZ complex
Fuchigami et al., Genes Cells 2013 : We reported previously that Cdk5-p35 phosphorylates Dab1 at Ser400 and Ser491 and the phosphorylation regulates its binding to CIN85 , which is an SH3 containing multiadaptor protein involved in endocytic downregulation of receptor-tyrosine kinases ... We reported previously that Cdk5-p35 phosphorylates Dab1 at Ser400 and Ser491 and the phosphorylation regulates its binding to CIN85 , which is an SH3 containing multiadaptor protein involved in endocytic downregulation of receptor-tyrosine kinases ... We reported previously that Cdk5-p35 phosphorylates Dab1 at Ser400 and Ser491 and the phosphorylation regulates its binding to CIN85 , which is an SH3 containing multiadaptor protein involved in endocytic downregulation of receptor-tyrosine kinases
Anderson et al., J Biol Chem 1997 : Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2 , Fyn, and phosphatidylinositol 3-kinase
Husson et al., Oncogene 1997 : We demonstrate here that CSF-1 exposure of stable transfectant CHO cells expressing the CSF-1 receptor induced the sustained tyrosine phosphorylation of c-Cbl and its subsequent association with Crk-II and the p85 kDa subunit of the PI 3-kinase, while it constitutively associates with Grb2