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FGF21 — KLB
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ogawa et al., Proc Natl Acad Sci U S A 2007
:
BetaKlotho is
required for metabolic activity of
fibroblast growth factor 21 ... Here, we show that
FGF21 activity
depends on
betaKlotho , a single-pass transmembrane protein whose expression is induced during differentiation from preadipocytes to adipocytes
Kurosu et al., J Biol Chem 2007
:
We demonstrated that Klotho and
betaKlotho , homologous single-pass transmembrane proteins that bind to FGFRs, are
required for metabolic activity of FGF23 and
FGF21 , respectively
Suzuki et al., Mol Endocrinol 2008
:
betaKlotho is
required for
fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c ... We report that in a reconstituted receptor activation assay system using BaF3 cells, which do not endogenously express any type of FGF receptor ( FGFR ) or heparan sulfate proteoglycan,
FGF21 alone does not activate FGFRs and that
betaKlotho is
required for FGF21 to activate two specific FGFR subtypes : FGFR1c and FGFR3c
Wu et al., J Biol Chem 2008
:
Both FGF23 and
FGF21 require intact alpha or
betaKlotho for signaling, respectively, whereas FGF19 can signal through a Klotho chimera consisting of the N terminus of alphaKlotho and the C terminus of betaKlotho
Yie et al., FEBS Lett 2009
:
Fibroblast growth factor-21 (FGF21) signaling
requires the presence of
beta-Klotho , a co-receptor with a very short cytoplasmic domain
Micanovic et al., J Cell Physiol 2009
(MAP Kinase Signaling System) :
FGF21 activity
depends on membrane protein
betaKlotho that physically complexes with various FGF receptors, thus conferring them the ability to bind FGF21 and activate downstream signaling pathways
Wu et al., Proc Natl Acad Sci U S A 2009
(Obesity) :
Further,
FGF19 activated FGFR4 signaling in the
presence or absence of
betaKlotho , but activation of FGFRs 1c, 2c, or 3c was completely betaKlotho dependent
Yang et al., Nutrition & metabolism 2012
:
Both FGF19 and
FGF21 activate
FGFR1-KLB whose function predominates in adipocytes