Horsch et al., Mol Endocrinol 2001
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Using an in-gel protein tyrosine phosphatase (PTP) assay, we observed that the activity of a 125-kDa PTP was up-regulated in HC11 cells in response to EGF Li et al., Arch Biochem Biophys 2003
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Importantly, PTP1B inhibition by nitrosothiols led to EGF receptor phosphorylation even in the absence of exogenously added EGF
Sörby et al., J Biol Chem 1996
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A PTP mediated decrease of the in vivo net levels of ligand induced tyrosine phosphorylation of EGF and platelet derived growth factor receptors in cells at high density have thus been demonstrated