Downing et al., Oncogene 1991
(Cell Transformation, Neoplastic) :
PDGF, CSF-1 , and EGF induced only a minimal increase in the tyrosine phosphorylation of p85 and no change in the phosphorylation of p110
Montenegro et al., Cell Prolif 2009
(Leukemia, Myeloid) :
PD98059, a selective inhibitor of MEK, blocked GM-CSF induced phosphorylation of MEK and ERK but not p85 al-Shami et al., Blood 1997
:
The results suggest that the activation of PI3-kinase by GM-CSF is mediated by the tyrosine phosphorylation of p85 and that this activation is downregulated by PKC possibly via the inhibition of lyn