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BCL2 — XIAP

Text-mined interactions from Literome

Fulda et al., Oncogene 2002 (Breast Neoplasms...) : Also, Bcl-2 blocked cleavage of XIAP and overexpression of XIAP conferred resistance against TRAIL indicating that apoptosis was also amplified through a feedforward loop between caspases and XIAP
Sinicrope et al., Clin Cancer Res 2004 (Colonic Neoplasms) : Bcl-2 inhibited TRAIL induced Bax translocation, cytosolic release of cytochrome c and Smac/DIABLO, and the downstream cleavage of XIAP and DFF45
Conradie et al., J Endocrinol 2007 : We assessed the transcriptional profiles of seven anti-apoptotic proteins ( Bcl-2 , Bcl-X ( L ), inhibitors of apoptosis protein-1 ( IAP-1 ), IAP-2, X-linked IAP (XIAP) , Fas associated death-domain-like IL-1beta converting enzyme-inhibitory protein ( FLIP ( Long ) ) and FLIP ( Short ) ) in osteoblasts subjected to various stimuli using real-time quantitative PCR
Li et al., Aging Cell 2007 : Aging up-regulated expression of Bax, Bcl2 and ARC, down-regulated XIAP expression and did not affect p53, pp53 and Omi/HtrA2
Nakano et al., Prostate Cancer Prostatic Dis 2009 (Neoplasms, Hormone-Dependent...) : We found that transient downregulation of XIAP by siRNAs resulted in an increase of apoptosis and a decrease in Bcl-2 levels and sensitized PCa cells to cisplatin