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BCL2 — ITPR1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: BCL2 — ITPR1 (affinity chromatography technology) White et al., Nat Cell Biol 2005*
• IRef Biogrid Interaction: BCL2 — ITPR1 (physical association, affinity chromatography technology) Oakes et al., Proc Natl Acad Sci U S A 2005*
• IRef Dip Interaction: ITPR1 — BCL2 (physical association, anti bait coimmunoprecipitation) Rong et al., Proc Natl Acad Sci U S A 2009*
• IRef Hprd Interaction: BCL2 — ITPR1 (in vitro) Oakes et al., Proc Natl Acad Sci U S A 2005*

Text-mined interactions from Literome

Oakes et al., Proc Natl Acad Sci U S A 2005 : These findings support a model in which BCL-2 family members regulate IP3R-1 phosphorylation to control the rate of ER Ca ( 2+ ) leak from intracellular stores
Machado-Vieira et al., Biol Psychiatry 2011 (Calcium Signaling) : The Bcl-2 gene polymorphism rs956572AA increases inositol 1,4,5-trisphosphate receptor mediated endoplasmic reticulum calcium release in subjects with bipolar disorder
Monaco et al., Cell Mol Life Sci 2013 (Calcium Signaling) : Furthermore, distinct Bcl-2-family members may selectively regulate inositol 1,4,5-trisphosphate receptor ( IP3R ) : Bcl-2 likely acts as an endogenous inhibitor of the IP3R, preventing pro-apoptotic Ca ( 2+ ) transients, while Bcl-XL likely acts as an endogenous IP3R sensitizing protein promoting pro-survival Ca ( 2+ ) oscillations