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APOB — IL1B

Text-mined interactions from Literome

Feng et al., Atherosclerosis 2001 : VK-19911 ( Pyridine, 4- [ 4- ( 4-fluorophenyl ) -1- ( 4-piperidinyl ) -1H-imidazol-5-yl ] -dihydrochloride ), a specific inhibitor of p38 alpha, prevented the induction of TNFalpha and IL-1 beta by oxidized LDL in a dose dependent manner
Frostegård et al., Arterioscler Thromb 1992 : Oxidized LDL also stimulated the release of interleukin-1 beta from monocytes ... The maximal effect of oxidized LDL on T-cell activation and interleukin-1 beta release occurred at a concentration of 1 micrograms/ml. Native LDL also had the capacity to activate T cells, although only at higher concentrations
Blázovics et al., Orv Hetil 2004 (Inflammatory Bowel Diseases) : It became known, that oxidized LDL can inhibit LPS induced binding of the NF-kappaB to DNA and the subsequent expression of TNF-alpha and interleukin-1beta in macrophages as well as oxidized LDL modulates activation of NF-kappaB in mononuclear phagocytes by altering the degradation of I-kappaBs
Ku et al., J Biol Chem 1992 : The purpose of the present study was to determine whether modified LDL could also induce macrophage release of interleukin 1 beta (IL-1 beta) , a cytokine which enhances vascular smooth muscle cell proliferation, another feature of the atherosclerotic process
Okumura et al., J Atheroscler Thromb 2006 (Leukemia, Myeloid) : Neither native LDL nor oxidized LDL ( OxLDL ) significantly increased IL-1beta release
Fong et al., J Lipid Res 1991 : Low density lipoprotein (LDL) , acetylated-LDL, or malondialdehyde-LDL did not induce IL-1 beta mRNA expression or affect the expression in response to lipopolysaccharide (LPS) ... A non-receptor pathway was supported by two lines of evidence : 1 ) the inhibition could be reproduced with a lipid extract, and 2 ) oxidized LDL also inhibited scavenger receptor negative THP-1 cell IL-1 beta mRNA expression
Virella et al., Clin Immunol Immunopathol 1995 : In conclusion, human macrophages are efficiently activated by LDL-IC , as reflected by the release of IL-1 beta and TNF alpha and by the release of oxygen active radicals
Thomas et al., J Lipid Res 1994 : Oxidized low density lipoproteins (LDL) induce the release of interleukin-1 beta (IL-1 beta) from human peripheral blood mononuclear cells, a process that may contribute to atherogenesis ... High Cu2+ to LDL ratios promoted extensive TBARS formation and these LDL were the most potent activators of IL-1 beta release, although LDL with TBARS greater than 50 nmol/mg protein were cytotoxic and IL-1 beta release was diminished ... Accordingly, dialysis of oxidized LDL removed nearly all aldehydes and rendered the LDL unable to induce IL-1 beta release
Kutteh et al., J Soc Gynecol Investig 1994 : Results demonstrated that treatment of cultured hepatocytes with TNF-alpha maximally inhibited Apo B production by 50 % at a half-maximal concentration of 100 pg/mL, whereas IL-1 beta maximally inhibited Apo B production by 80 % at a half-maximal dose of 200 pg/mL