◀ Back to STAT3
FAS — STAT3
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
FAS
→
STAT3
(decreases, FAS Activity)
Evidence: Downregulation of FAS expression is a common event during tumor progression and has been correlated with resistance to radiation or drug-induced cell death. Importantly, STAT3 binds directly to the FAS promoter in association with JUN to suppress the transcription of the death receptor.
-
OpenBEL Selventa BEL large corpus:
FAS
→
Complex of JUN-STAT3
(decreases)
Evidence: Downregulation of FAS expression is a common event during tumor progression and has been correlated with resistance to radiation or drug-induced cell death. Importantly, STAT3 binds directly to the FAS promoter in association with JUN to suppress the transcription of the death receptor.
Text-mined interactions from Literome
Ivanov et al., J Biol Chem 2002
:
Regulation of
Fas expression by
STAT3 and c-Jun is mediated by phosphatidylinositol 3-kinase-AKT signaling
Porras et al., Mol Biol Cell 2004
(MAP Kinase Signaling System) :
Phosphorylation of the transcription factor
STAT3 on Ser-727, mediated by the extracellular signal regulated kinase MAP kinase pathway, may
contribute to the decrease in both Bax and
Fas expression in p38 alpha-/- cells
Selvendiran et al., Cancer Res 2006
(Carcinoma, Hepatocellular...) :
Consistent with the increased Fas/CD95 expression, a drastic decrease in the Tyr ( 705 ) phosphorylation of
STAT3 , a known negative
regulator of
Fas/CD95 transcription, was found within 20 minutes in the luteolin treated cells, leading to down-regulation in the target gene products of STAT3, such as cyclin D1, survivin, Bcl-xL, and vascular endothelial growth factor