◀ Back to MAPK14
MAPK14 — NFATC1
Pathways - manually collected, often from reviews:
-
KEGG T cell receptor signaling pathway:
MAPK11/MAPK12/MAPK13/MAPK14
→
NFAT5/NFATC1/NFATC2/NFATC3/NFATC4
(protein-protein, activation)
-
NCI Pathway Database Role of Calcineurin-dependent NFAT signaling in lymphocytes:
NFATc/p38 alpha complex (NFATC1-MAPK14)
→
p38 alpha (MAPK14)
(modification, collaborate)
Porter et al., J Biol Chem 2000*
Evidence: assay, physical interaction
-
NCI Pathway Database Role of Calcineurin-dependent NFAT signaling in lymphocytes:
NFATc/p38 alpha complex (NFATC1-MAPK14)
→
NFATc (NFATC1)
(modification, collaborate)
Porter et al., J Biol Chem 2000*
Evidence: assay, physical interaction
-
NCI Pathway Database Role of Calcineurin-dependent NFAT signaling in lymphocytes:
p38 alpha (MAPK14)
→
NFATc (NFATC1)
(modification, collaborate)
Porter et al., J Biol Chem 2000*
Evidence: assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wu et al., Mol Cell Biol 2003
:
Fourth, p38
MAPK promoted the interaction of
NFATc with the coactivator CREB binding protein ... All together, the overall
effect of p38
MAPK on
NFATc in T cells is clear activation
Holsinger et al., Curr Biol 1998
:
Activation of Jun N-terminal kinase or stress activated kinase ( JNK or SAPK ) and
mitogen activated protein kinase ( MAPK ) and the
induction of the transcription factor
NF-ATc1 and egr-1 genes was normal