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BMP2 — WNT6
Text-mined interactions from Literome
McGrew et al., Mech Dev 1999
:
The co-activation of
Wnt signaling and concomitant
inhibition of
BMP signaling has previously been implicated in vertebrate neural patterning, as evidenced by the combinatorial induction of engrailed-2 and krox-20 in Xenopus
Fischer et al., J Cell Biochem 2002
:
To assess the functional
involvement of
Wnt signaling in
BMP-2 induced chondrogenesis, cultures were treated with lithium chloride, a Wnt-7A mimetic that acts by inhibiting the serine/threonine phosphorylation activity of glycogen synthase kinase-3beta ( GSK-3beta )
Nakashima et al., J Biol Chem 2005
:
This suppression is mediated by a GC-rich region of the BMP-2-responsive element of the Id1 gene promoter, and interaction between Smad1/4 and beta-catenin is crucial for
Wnt mediated suppression of the
BMP-2 response in C2C12 cells ... These findings identify functional cross-talk of Id1 expression between Wnt and BMP signaling and demonstrate a novel mechanism for
Wnt regulation of the
BMP-2 response, linking Id1 expression to Wnt/beta-catenin signaling
Dong et al., J Cell Physiol 2006
(Hypertrophy) :
Altogether we demonstrate that
Wnt/beta-catenin signaling is
regulated by TGF-beta and
BMP-2 in chick upper sternal chondrocytes, and mediates chondrocyte hypertrophy at least partly through activation of Runx2 which in turn may induce col10a1 expression
Liu et al., J Biol Chem 2006
:
Expression of a mutant Smad1 protein, which can not be phosphorylated in response to BMP, eliminated the inhibitory
effect of
BMP on
Wnt-inducedbeta-catenin accumulation and transcriptional activity
van Bezooijen et al., J Bone Miner Res 2007
:
In contrast, sclerostin shared many characteristics with the Wnt antagonist dickkopf-1 in antagonizing
BMP stimulated bone formation and BMP- and Wnt induced
Wnt reporter construct activation
Patthey et al., PloS one 2008
:
By using in vitro assays of neural crest and placodal cell differentiation, we now provide evidence that
Wnt signals impose caudal character on neural plate border cells at the late gastrula stage, and that under these conditions,
BMP signals
induce neural crest instead of rostral placodal cells
Kami et al., PloS one 2008
:
Furthermore,
BMP2 inhibited
Wnt/beta-catenin signaling that promoted CL6 cardiomyogenesis
Patthey et al., Development 2009
:
Our results indicate, however, that at this stage
BMP signals can
induce neural plate border cells only when
Wnt activity is blocked, and that the two signals in combination generate epidermal cells
Sato et al., Genes Cells 2009
:
Bone morphogenetic protein-2 enhances
Wnt/beta-catenin signaling induced osteoprotegerin expression
Steventon et al., Development 2009
:
By performing tissue recombination experiments and using specific inhibitors of different inductive signals, we show that the first inductive step requires
Wnt activation and
BMP inhibition , whereas the later maintenance step requires activation of both pathways
Kamiya et al., Curr Mol Pharmacol 2012
(Bone Resorption) :
We recently generated an osteoblast targeted deletion of BMP signaling using a Cre-loxP strategy and found that
BMP signaling in osteoblasts can
inhibit Wnt signaling through the Wnt inhibitors DKK1 and SOST
Papathanasiou et al., Arthritis Res Ther 2012
(Hypertrophy...) :
Bone morphogenetic protein-2 induced
Wnt/ß-catenin signaling pathway
activation through enhanced low-density-lipoprotein receptor related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes
Kim et al., Biochem Biophys Res Commun 2012
(Wnt Signaling Pathway) :
During vertebrate heart valve formation,
Wnt/ß-catenin signaling
induces BMP signals in atrioventricular canal ( AVC ) myocardial cells and underlying AVC endocardial cells then undergo endothelial-mesenchymal transdifferentiation ( EMT ) by receiving this BMP signals
Klaus et al., Proc Natl Acad Sci U S A 2012
(Wnt Signaling Pathway) :
Using FACS enrichment of cardiac progenitors in RBPJ and RBPJ/Axin2 mutants, embryo cultures in the presence of the Bmp inhibitor Noggin, and by crossing a Bmp4 mutation into the RBPJ/Axin2 mutant background, we show that Wnt and Bmp4 signaling activate specific and nonoverlapping cardiac-specific genes in the cardiac progenitors : Nkx2-5, Isl1 and Baf60c are controlled by
Wnt/ß-catenin , and Gata4, SRF, and Mef2c are
controlled by
Bmp signaling
Zhang et al., Bone 2013
:
Wnt/ß-catenin signaling
activates bone morphogenetic protein 2 expression in osteoblasts ... Activation of
Wnt signaling by Wnt3a or overexpression of ß-catenin/TCF4 both
stimulated BMP2 transcription at promoter and mRNA levels
Wang et al., PloS one 2013
:
Whole embryo cultures treated with Wnt4 or Wnt inhibitory factor 1 (Wif1) show that
Bmp2 expression in the AVC myocardium is
dependent on
Wnt activity ; Wnt4 also reinstates Bmp2 expression in the AVC myocardium of endocardial Notch1 null embryos
Hoppler et al., Mech Dev 1998
:
Although
BMP-2/-4 signaling
regulates Wnt-8 expression, these genes do not function in a linear pathway because Wnt-8 overexpression can not compensate for an inhibition of BMP-2/-4 function, but rather BMP-4 overexpression rescues ventral gene expression in embryos with inhibited Wnt-8 function
Godin et al., Development 1998
:
By contrast,
BMP7 expression in the metanephric mesenchyme is
dependent on proteoglycans and possibly
Wnt signaling