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FBXW7 — TP53

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of CUL1-FBXW7-RBX1-SKP1 → TP53 (increases)
  Evidence: p53 might induce Cyclin E degradation via upregulation of Fbw7.

Text-mined interactions from Literome

Mao et al., Nature 2004 (Cell Transformation, Neoplastic...) : We propose that p53 dependent loss of Fbxw7 leads to genetic instability by mechanisms that might involve the activation of Aurora-A, providing a rationale for the early occurrence of these mutations in human cancers
Yokobori et al., Cancer Res 2009 (Stomach Neoplasms) : In conclusion, we showed a role for p53 in the transcriptional regulation of FBXW7 expression in clinical gastric cancer cases and showed that disruption of both p53 and FBXW7 contributes to poor prognosis