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IRF7 — TLR2

Text-mined interactions from Literome

Guiducci et al., J Exp Med 2008 : PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation
So et al., Glia 2009 (Cardiovirus Infections) : TMEV infection led to TLR2 mediated NF-kappaB activation, but not IRF3 or IRF7 activation, critical for type I IFN production
Atzei et al., J Biol Chem 2010 : We now describe the first functional characterization of the human ortholog of Cactin ( hCactin ) and show that it acts as a negative regulator of TLRs. Overexpression of hCactin suppresses TLR induced activation of NF-?B and interferon-regulatory factor transcription factors and induction of TLR-responsive genes, whereas knockdown of endogenous hCactin augments TLR induction of these responses
Sisirak et al., Int J Cancer 2013 (Breast Neoplasms) : Mechanisms of type I IFN inhibition did not involve TLR downregulation but the inhibition of IRF-7 expression and nuclear translocation in pDC after their exposure to tumor derived supernatants or recombinant TGF-ß1 and TNF-a