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FES — STAT3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kim et al., J Biol Chem 2003
:
Further analysis showed that
Fes ( act )
caused activation of CCAAT/enhancer binding protein-alpha and
STAT3 , two transcription factors that are involved in granulocyte differentiation
Nelson et al., J Biol Chem 1998
:
In this report, we provide direct evidence that
c-Fes , the normal human homolog of v-Fps, potently
activates STAT3 ... To determine whether
Fes induced
STAT3 activation is dependent upon endogenous mammalian kinases, co-expression studies were also performed in Sf-9 insect cells ...
Fes also induced a dramatic
increase in
STAT3 DNA binding activity in this system, whereas no activation of STAT5 was observed ...
Fes induced strong tyrosine phosphorylation of
STAT3 in both expression systems, consistent with the gel-shift results