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ALK — SMAD9
Text-mined interactions from Literome
DaCosta Byfield et al., Mol Pharmacol 2004
:
We demonstrate that this compound selectively and concentration-dependently inhibits ALK4-, ALK5-, and ALK 7-dependent activation of downstream cytoplasmic signal transducers, Smad2 and Smad3, and of TGF-beta induced mitogen activated protein kinase pathway components but does not alter ALK1, ALK2, ALK3 or
ALK6 induced
Smad signaling
Luo et al., J Biol Chem 2010
:
Likewise, RNAi silencing of
ALK1 and ALK2 expression
inhibits BMP9 induced
BMPR-Smad activity and osteogenic differentiation in MSCs both in vitro and in vivo