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MMP9 — SAA1

Text-mined interactions from Literome

Lee et al., Biochem Biophys Res Commun 2005 : In the present study, we found that serum amyloid A (SAA) stimulated matrix-metalloproteinase-9 (MMP-9) upregulation at the transcription and translational levels in THP-1 cells ... SAA stimulated the activation of nuclear factor kappaB (NF-kappaB), which was required for the MMP-9 upregulation by SAA ... Formyl peptide receptor like 1 (FPRL1) was found to be involved in the upregulation of MMP-9 by SAA ... Among several FPRL1 agonists, including Trp-Lys-Tyr-Met-Val-D-Met ( WKYMVm ), SAA selectively stimulated MMP-9 upregulation
Ray et al., J Immunol 2005 (Arthritis) : Using progressively deleted and mutant promoter constructs of MMP-9, we show that serum amyloid A-activating factor ( SAF)-1 , a novel transcription factor, and the AP-1 family of proteins cooperatively regulate cytokine mediated induction of MMP-9 in the resident cells of the joint capsule
Connolly et al., Arthritis Rheum 2012 (Arthritis, Rheumatoid...) : The effects of A-SAA on MMP/TIMP expression on RA fibroblast-like synoviocytes ( FLS ), primary human chondrocytes, and RA/psoriatic arthritis synovial explant cultures were assessed using real-time polymerase chain reaction, enzyme linked immunosorbent assay, antibody protein arrays, and gelatin zymography ... A-SAA increased MMP-1, MMP-3 , MMP-13, and MMP/TIMP expression in RA FLS and synovial explants ( P < 0.05 ) ... Gelatin zymography revealed that A-SAA induced MMP-2 and MMP-9 activity ... In chondrocytes, A-SAA induced MMP-1, MMP-3 , and MMP-13 messenger RNA and protein expression ( all P < 0.01 ), resulting in a significant shift in MMP : TIMP ratios ( P < 0.05 )
Migita et al., Lab Invest 1998 (Arthritis, Rheumatoid) : When SAA containing media were immunodepleted by anti-SAA-specific antibody, SAA mediated MMP secretion was also abrogated