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CDH1 — PTEN
Text-mined interactions from Literome
Li et al., Biochem Biophys Res Commun 2007
(Breast Neoplasms) :
We reported here that
PTEN expression could be
controlled by overexpression or knock-down of
E-cadherin in several mammary carcinoma cell lines
Fournier et al., Cancer Res 2009
:
These studies provide evidence that
E-cadherin regulates both the
PTEN protein levels and its recruitment to cell-cell junctions in three-dimensional lrECM, indicating a dynamic reciprocity between architectural integrity and the levels and localization of PTEN
Song et al., Cell 2011
(Prostatic Neoplasms) :
Nuclear
PTEN regulates the
APC-CDH1 tumor-suppressive complex in a phosphatase independent manner ... Here we show that nuclear
PTEN interacts with APC/C,
promotes APC/C association with
CDH1 , and thereby enhances the tumor-suppressive activity of the APC-CDH1 complex ... We find that nuclear exclusion but not phosphatase inactivation of
PTEN impairs
APC-CDH1
Lau et al., Oncogene 2011
(Ovarian Neoplasms) :
Finally, we found that
E-cadherin negatively
regulates tumor cell growth, in part, by positively regulating
PTEN expression via ß-catenin mediated Egr1 regulation, thus influencing PI3K/Akt signaling
Chen et al., Mol Med Report 2013
(Breast Neoplasms) :
miRNA-200c increases the sensitivity of breast cancer cells to doxorubicin through the suppression of
E-cadherin mediated
PTEN/Akt signaling