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KITLG — PI3

Text-mined interactions from Literome

Blume-Jensen et al., Nat Genet 2000 : To examine the function of SCF induced phosphatidylinositol (PI) 3'-kinase activation in vivo, we employed the Cre-loxP system to mutate the codon for Tyr719, the PI 3'-kinase binding site in Kit/SCF-R, to Phe in the genome of mice by homologous recombination
Feng et al., J Biol Chem 2000 : We now demonstrate that SCF activates phosphoinositide 3-kinase (PI3-K) and p70 S6 kinase (p70S6K) and that rapamycin, a FRAP/mammalian target of rapamycin dependent inhibitor of p70S6K, completely inhibited bromodeoxyuridine incorporation induced by SCF in primary cultures of spermatogonia
Krystal et al., Mol Cancer Ther 2002 (Carcinoma, Small Cell...) : Both stem cell factor (SCF) and insulin-like growth factor (IGF)-I, components of prominent small cell lung cancer ( SCLC ) autocrine loops, as well as FCS, can potently activate phosphatidylinositol 3-kinase (PI3K)-Akt signaling, albeit with different kinetics
Grech et al., Blood 2008 : Stem cell factor (SCF) induced activation of phosphoinositide-3-kinase (PI3K) is required for transient amplification of the erythroblast compartment
Blume-Jensen et al., J Biol Chem 1994 : In conclusion, SCF induced PI-3'-kinase activation paralleled the increased SCF induced mitogenicity after inhibition of PKC