Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Visone et al., Endocr Relat Cancer 2007 (Carcinoma, Papillary...) : It is likely that the negative regulation of p27 ( Kip1 ) by miR-221 and miR-222 might also have a role in vivo since we report an inverse correlation between miR-221 and miR-222 up-regulation and down-regulation of the p27 ( Kip1 ) protein levels in human thyroid papillary carcinomas
Kim et al., Nucleic Acids Res 2009 (Stomach Neoplasms) : Furthermore, miR-106b and miR-93 control p21 while miR-222 and miR-221 regulate both p27 and p57
Sredni et al., Childs Nerv Syst 2010 (Brain Neoplasms...) : Here, we demonstrated the negative regulation of p27 ( Kip1 ) by miR-221/222 in ATRT using microarray, real-time reverse transcriptase polymerase chain reaction, and immunohistochemistry
Zhang et al., Leukemia & lymphoma 2012 (Lymphoma) : Overexpression of miR-297b-5p/3p also led to altered expression of p27 ( Kip1 ) and proliferating cell nuclear antigen, abnormal cell cycle arrest, decreased cell proliferation, migration and invasion in vitro in cell cultures, and suppressed xenograft tumor growth in vivo in the nude mouse