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MDM2 — RAF1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of RAF1-MAPK1-MAPK3-MDM2 (association, anti tag coimmunoprecipitation) Beaulieu et al., Cell 2008*

Text-mined interactions from Literome

Halaschek-Wiener et al., Cell Signal 2004 (Carcinoma...) : Consistent with the Ras/Raf/MEK/ERK mediated control of Mdm2 , treatment of SW480 cells with the Ras inhibitor FTS caused a marked ( 80 % ) decrease in Mdm2, which itself would account for the increase in p53
Phelps et al., J Biol Chem 2005 : Growth and survival factor activated Ras-Raf-MEK-ERK signaling can also regulate Hdm2 expression independently of p53, contributing to the pro-survival effect of these factors