UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to LRP6

DKK2 — LRP6

Pathways - manually collected, often from reviews:

BioCarta wnt lrp6 signalling: DKK2/LRP6/KRM2 complex (DKK2-LRP6-KREMEN2) → LRP6 (modification, collaborate)
BioCarta wnt lrp6 signalling: DKK2/LRP6/KRM2 complex (DKK2-LRP6-KREMEN2) → DKK2 (modification, collaborate)
BioCarta wnt lrp6 signalling: DKK2/LRP6/KRM2 complex (DKK2-LRP6-KREMEN2) → KRM2 (KREMEN2) (modification, collaborate)
BioCarta wnt lrp6 signalling: LRP6 → DKK2 (modification, collaborate)
KEGG Wnt signaling pathway: DKK1/DKK2/DKK4 → LRP5/LRP6 (protein-protein, inhibition)
NCI Pathway Database Presenilin action in Notch and Wnt signaling: DKK1 (DKK1) → DKK2/LRP6/Kremen 2 complex (DKK2-LRP6-KREMEN2) (modification, collaborate)
Mao et al., Nature 2001
Evidence: assay, other species
NCI Pathway Database Presenilin action in Notch and Wnt signaling: Kremen 2 (KREMEN2) → DKK2/LRP6/Kremen 2 complex (DKK2-LRP6-KREMEN2) (modification, collaborate)
Mao et al., Nature 2001
Evidence: assay, other species
NCI Pathway Database Presenilin action in Notch and Wnt signaling: DKK2 (DKK2) → DKK1/LRP6/Kremen 2 complex (DKK1-LRP6-KREMEN2) (modification, collaborate)
Mao et al., Nature 2001
Evidence: assay, other species
NCI Pathway Database Presenilin action in Notch and Wnt signaling: DKK2 (DKK2) → LRP6 (LRP6) (modification, collaborate) Mao et al., Nature 2001
Evidence: assay, other species
NCI Pathway Database Presenilin action in Notch and Wnt signaling: DKK2 (DKK2) → DKK2/LRP6/Kremen 2 complex (DKK2-LRP6-KREMEN2) (modification, collaborate)
Mao et al., Nature 2001
Evidence: assay, other species
NCI Pathway Database Presenilin action in Notch and Wnt signaling: DKK1/LRP6/Kremen 2 complex (DKK1-LRP6-KREMEN2) → DKK2/LRP6/Kremen 2 complex (DKK2-LRP6-KREMEN2) (modification, collaborate)
Mao et al., Nature 2001
Evidence: assay, other species
NCI Pathway Database Presenilin action in Notch and Wnt signaling: LRP6 (LRP6) → DKK2/LRP6/Kremen 2 complex (DKK2-LRP6-KREMEN2) (modification, collaborate)
Mao et al., Nature 2001
Evidence: assay, other species
NCI Pathway Database Presenilin action in Notch and Wnt signaling: DKK2/LRP6/Kremen 2 complex (DKK2-LRP6-KREMEN2) → DKK1/LRP6/Kremen 2 complex (DKK1-LRP6-KREMEN2) (degradation, collaborate)
Mao et al., Nature 2002
Evidence: assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Dip Interaction: LRP6 — DKK2 (direct interaction, bio-layer interferometry) Bourhis et al., Structure 2011 *
IRef Hprd Interaction: LRP6 — DKK2 (in vivo) Mao et al., Nature 2001, Li et al., J Biol Chem 2002 *
IRef Ophid Interaction: LRP6 — DKK2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Mao et al., Gene 2003 : In human 293 fibroblasts transfected dkk2 activates LRP6 signaling
Bao et al., Science signaling 2012 : The structural basis of DKK mediated inhibition of Wnt/LRP signaling