Gene interactions and pathways from curated databases and text-mining

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JUN — PLCG1

Text-mined interactions from Literome

Qu et al., Blood 2004 : The antigen induced tyrosine phosphorylation of FcepsilonRI, Syk, phospholipase C-gamma (PLC-gamma) , activation of c-Jun N-terminal kinase (JNK) , extracellular signal regulated kinase ( ERK ), inhibitor of nuclear factor kappaB kinase ( IKK ), and Ca++ influx were all suppressed in the cells overexpressing Cbl-b in the lipid raft
Yang et al., J Biol Chem 2008 (MAP Kinase Signaling System) : Lastly, we examined the role of the immediate-early transcription factors AP-1 and NF-kappaB and have found that phospholipase C-gamma dependent c-Jun and ERK dependent c-fos, but not the NF-kappaB, are strongly activated by bFGF, which in turn regulates the neuronal differentiation of BMSCs
Fu et al., J Exp Med 2010 (Autoimmune Diseases...) : We demonstrate that PLCgamma1 deficiency affects positive and negative selection, significantly reduces single positive thymocytes and peripheral T cells, and impairs TCR induced proliferation and cytokine production, and the activation of ERK, JNK, AP-1 , NFAT, and NF-kappaB