Gene interactions and pathways from curated databases and text-mining

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ACE — JUN

Text-mined interactions from Literome

Yoshiyama et al., J Mol Cell Cardiol 2001 (Myocardial Infarction) : ACE inhibitor and ARB inhibited JNKs, NF- kappa B and AP-1 activities
Kohlstedt et al., Circ Res 2004 : Mitogen activated protein kinase kinase 7 and c-Jun N-terminal kinase (JNK) coprecipitated with ACE, and stimulation of endothelial cells with ACE inhibitors increased the activity of ACE associated JNK and elicited the accumulation of phosphorylated c-Jun in the nucleus
Watanabe et al., Peptides 2006 : Furthermore, both an angiotensin-converting-enzyme (ACE) inhibitor and an AT1 receptor antagonist enhanced ( rather than reduced ) the NF-kappaB and AP-1 activities in the hippocampus and/or cerebellum of rats given LPS